Evidence map›Paper›PMID 36253506›Full record

SynthesisPediatric research2023

Cow's Milk-related Symptom Score for cow's milk allergy assessment: a meta-analysis for test accuracy.

Khaled Saad, Anas Elgenidy, Mostafa Atef, Mostafa K Abdelsattar, Mahmoud Al-Ashwah, Emad M Hammad, Faisal-Alkhateeb Ahmed, Amir Aboelgheet, Mohamed Shawky Elfarargy, Ahmad M Ali and 4 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Khaled Saad *Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt. khaled.ali@med.au.edu.eg.ORCID 0000-0002-8473-6116
Anas Elgenidy *Faculty of Medicine, Cairo University, Cairo, Egypt.
Mostafa AtefFaculty of Medicine, Cairo University, Cairo, Egypt.
Mostafa K AbdelsattarFaculty of Medicine, Cairo University, Cairo, Egypt.
Mahmoud Al-AshwahFaculty of Medicine, Cairo University, Cairo, Egypt.
Emad M HammadPediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Faisal-Alkhateeb AhmedPediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Amir AboelgheetPediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mohamed Shawky ElfarargyDepartment of Pediatrics, College of Medicine, Jouf University, Sakaka, Kingdom of Saudi Arabia.
Ahmad M AliPediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Amira H El-AshryMedical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Hamad Ghaleb DailahResearch and Scientific Studies Unit, College of Nursing, Jazan University, Jazan, Saudi Arabia.
Amira ElhoufeyDepartment of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.
Samaher F TahaPediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Assiut University · EGCairo University · EGJazan University · SAJouf University · SAMansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to assess the ability of Cow's Milk-related Symptom Score (CoMiss) in screening cow's milk protein allergy (CMPA) and assess validation of its sensitivity and specificity.

methodsWe searched the PubMed, WOS, Embase, and Ovid databases using broad terms and keywords for the concepts of the symptom-based score (CoMiss) and cow's milk allergy. We performed the meta-analyses using a meta-package of R software and Meta-DiSc software.

resultsFourteen studies were included with a total of 1238 children. At cut-off value 12, CoMiss had a pooled sensitivity of 0.64 and a pooled specificity of 0.75. The PLR and NLR were 3.05 and 0.5, respectively. The AUC value of the sROC curve was 0.7866. CoMiss showed a significant difference in CMPA patients at baseline and after milk elimination for 2-4 weeks (MD, 7.18), as well as between the CMPA-positive group compared with the CMPA-negative group, however, the statistical significancy was obtained after leave study of Selbuz et al. out of the analysis (MD, 4.61).

conclusionsCoMiss may be a promising symptom score in the Awareness of the symptoms related to cow's milk allergy and a useful tool in monitoring the response to a cow's milk-free diet. IMPACT: Cow's milk protein allergy (CMPA) is the most frequent food allergy in children under the age of 3 years. Cow's Milk-related Symptom Score (CoMiss) is a clinical scoring system to assist primary healthcare providers in early detection of CMPA We performed a meta-analysis of CoMiss test accuracy. Our findings reflect that CoMiss may be a promising symptom score in CMPA awareness and a useful tool in monitoring the response to a cow's milk-free diet.

Indexed as

Milk HypersensitivityAllergensAnimalsCattleDatabases, FactualFemaleMilkMilk ProteinsSensitivity and SpecificityAllergensMilk Proteins

Identifiers

PMID36253506
OpenAlexW4306409849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.