ArticleNature communications2022
A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis.BMJ global health · 2024Pooled it
- A replication-incompetent adenovirus type 55 vaccine induces broad and durable protective immunity against pathogenic adenoviruses.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Association of COVID-19 vaccination before 12 weeks of gestation with ultrasound-detected congenital anomalies compared with later or no vaccination: A registry-based cohort study.SAGE open medicine · 2026Article
- First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies.JAMA network open · 2025Article
- Impact of SARS-CoV-2 Infection on the Course of Pregnancy and Birth After Assisted Reproduction.Geburtshilfe und Frauenheilkunde · 2025Article
- COVID-19 vaccination around the time of conception and risk of placenta-mediated adverse pregnancy outcomes.Acta obstetricia et gynecologica Scandinavica · 2025Article
- The Effectiveness and Influence of COVID-19 Vaccination on Perinatal Individuals and Their Newborns: An Updated Meta-Analysis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Review
- Building on the COVID-19 in Pregnancy in Scotland study to support ongoing surveillance, research, and pandemic preparedness for maternal and child health.Journal of global health · 2024Article
- COVID-19 diagnosis, vaccination during pregnancy, and adverse pregnancy outcomes of 865,654 women in England and Wales: a population-based cohort study.The Lancet regional health. Europe · 2024Article
- Safety of COVID-19 Vaccination in Pregnancy: A Systematic Review.Diagnostics (Basel, Switzerland) · 2024Review
- Defining and reporting adverse events of special interest in comparative maternal vaccine studies: a systematic review.Vaccine: X · 2024Review
- Assisted reproduction after SARS-CoV-2-infection: results of a single-center cohort-study.Archives of gynecology and obstetrics · 2024Article
- SARS-CoV-2 infection in IVF-conceived early pregnancy and the risk of miscarriage: a matched retrospective cohort study.Human reproduction open · 2024Article
- The effect of coronavirus disease 2019 vaccination on pregnant women: A scoping review.Health SA = SA Gesondheid · 2024Review
- Vaccination, immunity, and the changing impact of COVID-19 on infant health.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A prospective cohort study of preconception COVID-19 vaccination and miscarriage.Human reproduction (Oxford, England) · 2023Article
- Neonatal and maternal outcomes following SARS-CoV-2 infection and COVID-19 vaccination: a population-based matched cohort study.Nature communications · 2023Article
- A population-based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection.Nature communications · 2023Article
- A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection.Nature communications · 2022Article
Corrections and comments
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Authors and funding
28 authors at 9 institutions in 2 countries.
Funding
Abstract
Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96-1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92-1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.