Evidence map›Paper›PMID 36253453›Full record

ArticleGene therapy2023

IgG-cleavage protein allows therapeutic AAV gene delivery in passively immunized MPS IIIA mice.

Tierra A Bobo, Preston N Samowitz, Michael I Robinson, Laura I Montes, Lawrence J Forsberg, Richard Feng, Nathan I Nicely, Haiyan Fu

Abstract read
PubMed Publisher
In one paragraph

Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Binding and neutralizing anti-AAV antibodies: Detection and implications for rAAV-mediated gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tierra A Bobo *Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Preston N Samowitz *Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-3940-303X
Michael I RobinsonGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-9030-9399
Laura I MontesGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lawrence J ForsbergProtein Production & Purification Core, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Richard FengProtein Production & Purification Core, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nathan I NicelyProtein Production & Purification Core, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Haiyan FuGene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. hfu@email.unc.edu.ORCID 0000-0003-0518-3726
University of North Carolina at Chapel Hill · US

Funding

Development of gene therapy product for treating MPS IIIBR41NS115232 · NINDS · NEUROGT, INC. · PI FU, HAIYAN · 2020 to 2021
$682k
Rapid Transient Depletion of Pre-existing Antibodies for rAAV Gene DeliveryR21AI146653 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FU, HAIYAN · 2019 to 2020
$428k
NIAID NIH HHS R21AI146653NINDS NIH HHS R41 NS115232
6 · The paper itself

Abstract

The widespread pre-existing αAAV-Abs in humans pose a critical challenge in translation of AAV gene therapy. The IgG degrading enzyme of Streptococci (IdeS) is demonstrated to specifically cleave IgG of humans and other species (not mouse). This study developed a modified new modified IdeS protein product (IdeS

Indexed as

Bacterial ProteinsMucopolysaccharidosis IIIAnimalsGenetic TherapyHumansImmunoglobulin GMiceRabbitsBacterial ProteinsImmunoglobulin G

Identifiers

PMID36253453
OpenAlexW4306377442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.