Evidence map›Paper›PMID 36253440›Full record

SynthesisMolecular psychiatry2023

Genome-wide association study meta-analysis of suicide death and suicidal behavior.

Qingqin S Li, Andrey A Shabalin, Emily DiBlasi, Srihari Gopal, Carla M Canuso, FinnGen, International Suicide Genetics Consortium, Aarno Palotie, Wayne C Drevets, Anna R Docherty, Hilary Coon

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Autism, youth suicide, and psychedelics: A review of the 21st century evidence.Journal of the Chinese Medical Association : JCMA · 2024
    Pooled it
  2. Article
  3. Network analysis of the genetic relationships between twenty psychiatric and substance use disorders.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A century of suicide: Insights from long-term data in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Mapping the genetic landscape of suicide risk: Insights from genomic SEM.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Qingqin S LiNeuroscience, Janssen Research & Development, Titusville, NJ, 08560, USA. qli2@its.jnj.com.ORCID 0000-0003-4182-4535
Andrey A ShabalinHuntsman Mental Health Institute, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.ORCID 0000-0003-0309-6821
Emily DiBlasiHuntsman Mental Health Institute, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Srihari GopalNeuroscience, Janssen Research & Development, Titusville, NJ, 08560, USA.ORCID 0000-0001-5254-2192
Carla M CanusoNeuroscience, Janssen Research & Development, Titusville, NJ, 08560, USA.
FinnGen, International Suicide Genetics Consortium
Aarno PalotieInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-2527-5874
Wayne C DrevetsNeuroscience, Janssen Research & Development, San Diego, CA, 92121, USA.
Anna R DochertyHuntsman Mental Health Institute, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.ORCID 0000-0001-7139-7007
Hilary CoonHuntsman Mental Health Institute, Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Janssen (United States) · USUniversity of Utah · USRegeneron (United States) · USUniversity of Helsinki · FIVirginia Commonwealth University · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Prediction of suicide death using EHR and polygenic risk scoresR01MH123489 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI COON, HILARY · 2020 to 2025
$4.2M
Genetic analysis of high-risk Utah suicide pedigreesR01MH099134 · NIMH · UNIVERSITY OF UTAH · PI COON, HILARY · 2013 to 2017
$3.9M
Genome-Wide Association Analysis of Suicide DeathR01MH123619 · NIMH · UNIVERSITY OF UTAH · PI DOCHERTY, ANNA R. · 2020 to 2024
$3.2M
Integrating Genomic and Environmental Perspectives on Internalizing DisordersK01MH093731 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ADKINS, DANIEL E · 2011 to 2015
$649k
NCATS NIH HHS UL1 TR002538NCI NIH HHS P30 CA042014NIMH NIH HHS K01 MH093731NIMH NIH HHS R01 MH099134NIMH NIH HHS R01 MH123489NIMH NIH HHS R01 MH123619
6 · The paper itself

Abstract

Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated with suicide death and suicidal behavior. Meta-analysis for suicide death was performed using 3765 cases from Utah and matching 6572 controls of European ancestry. Meta-analysis for suicidal behavior using data across five cohorts (n = 8315 cases and 256,478 psychiatric or populational controls of European ancestry) was also performed. One locus in neuroligin 1 (NLGN1) passing the genome-wide significance threshold for suicide death was identified (top SNP rs73182688, with p = 5.48 × 10

Indexed as

Suicidal IdeationSuicideGenome-Wide Association StudyHumansRisk FactorsSuicide, Attempted

Identifiers

PMID36253440
PMCPMC9908547
OpenAlexW4306404616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.