Evidence map›Paper›PMID 36253437›Full record

ArticleCommunications biology2022

Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma.

Xikun Han, Zhaozhong Zhu, Qian Xiao, Jun Li, Xiumei Hong, Xiaobin Wang, Kohei Hasegawa, Carlos A Camargo, Liming Liang

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pharmacogenetics of childhood uncontrolled asthma.Expert review of clinical immunology · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Advancing precision public health for obesity in children.Reviews in endocrine & metabolic disorders · 2023
    Review
  17. Asthma Phenotypes in the Era of Personalized Medicine.Journal of clinical medicine · 2023
    Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xikun HanDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA. hanxikun2017@gmail.com.ORCID 0000-0002-3823-7308
Zhaozhong ZhuDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5662-1541
Qian XiaoDepartment of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA, USA.
Jun LiDepartment of Nutrition, Harvard T H Chan School of Public Health, Boston, MA, USA.ORCID 0000-0003-3519-8638
Xiumei HongCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-4451-302X
Kohei HasegawaDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5739-7999
Carlos A CamargoDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-5071-7654
Liming LiangDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA. lliang@hsph.harvard.edu.ORCID 0000-0001-8261-3174
Harvard University · USJohns Hopkins University · USMassachusetts Department of Public Health · US

Funding

Infant blood epigenome and risks of IgE sensitization, obesity, and asthma: MARC-35/43 cohortsR01AI148338 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CAMARGO, CARLOS ARTURO, LIANG, LIMING · 2020 to 2023
$2.5M
Integrating the genome, metabolome, and microbiome for childhood asthma: Risk and endotypesK01AI153558 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ZHU, ZHAOZHONG · 2021 to 2025
$663k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NIAID NIH HHS K01 AI153558NIAID NIH HHS R01 AI148338
6 · The paper itself

Abstract

Obesity and asthma are both common diseases with high population burden worldwide. Recent genetic association studies have shown that obesity is associated with asthma in adults. The relationship between childhood obesity and childhood asthma, and the underlying mechanisms linking obesity to asthma remain to be clarified. In the present study, leveraging large-scale genetic data from UK biobank and several other data sources, we investigated the shared genetic components between body mass index (BMI, n = 39620) in children and childhood asthma (n

Indexed as

AsthmaPediatric ObesityAdiponectinAdultBayes TheoremBiomarkersBody Mass IndexChildGenome-Wide Association StudyHumansInterleukin-6Polymorphism, Single NucleotideAdiponectinBiomarkersInterleukin-6

Identifiers

PMID36253437
PMCPMC9576683
OpenAlexW4306407097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.