Evidence map›Paper›PMID 36253353›Full record

ArticleNature communications2022

Vesicular release probability sets the strength of individual Schaffer collateral synapses.

Céline D Dürst, J Simon Wiegert, Christian Schulze, Nordine Helassa, Katalin Török, Thomas G Oertner

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 41 citations in OpenAlex.

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  14. Non-canonical function of ADAM10 in presynaptic plasticity.Cellular and molecular life sciences : CMLS · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Céline D DürstInstitute for Synaptic Physiology, Center for Molecular Neurobiology Hamburg (ZMNH), 20251, Hamburg, Germany.ORCID 0000-0003-3821-2888
J Simon WiegertInstitute for Synaptic Physiology, Center for Molecular Neurobiology Hamburg (ZMNH), 20251, Hamburg, Germany.ORCID 0000-0003-0893-9349
Christian SchulzeInstitute for Synaptic Physiology, Center for Molecular Neurobiology Hamburg (ZMNH), 20251, Hamburg, Germany.
Nordine HelassaCell Biology and Genetics Research Centre, Molecular and Clinical Sciences Research Institute, St George's, University of London, London, SW17 0RE, UK.ORCID 0000-0003-3743-1886
Katalin TörökCell Biology and Genetics Research Centre, Molecular and Clinical Sciences Research Institute, St George's, University of London, London, SW17 0RE, UK.ORCID 0000-0002-3107-4534
Thomas G OertnerInstitute for Synaptic Physiology, Center for Molecular Neurobiology Hamburg (ZMNH), 20251, Hamburg, Germany. thomas.oertner@zmnh.uni-hamburg.de.ORCID 0000-0002-2312-7528
Hamburg Institut (Germany) · DESt George's, University of London · GBUniversity of Geneva · CHUniversity of Liverpool · GB

Funding

British Heart Foundation FS/17/56/32925
6 · The paper itself

Abstract

Information processing in the brain is controlled by quantal release of neurotransmitters, a tightly regulated process. From ultrastructural analysis, it is known that presynaptic boutons along single axons differ in the number of vesicles docked at the active zone. It is not clear whether the probability of these vesicles to get released (p

Indexed as

CalciumSynaptic VesiclesGlutamic AcidHippocampusNeurotransmitter AgentsPresynaptic TerminalsProbabilitySynapsesSynaptic TransmissionCalciumGlutamic AcidNeurotransmitter Agents

Identifiers

PMID36253353
PMCPMC9576736
OpenAlexW4306407129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.