ArticleJournal of the American Society of Nephrology : JASN2022
Anatomical Evidence for Parasympathetic Innervation of the Renal Vasculature and Pelvis.
Article in Journal of the American Society of Nephrology : JASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 40 citations in OpenAlex.
- Aorticorenal Ganglion Ablation Enhances Blood Pressure Reduction After Renal Denervation.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Tubulointerstitial inflammation in glomerular diseases: mechanistic pathways, prognostic value, and translational therapeutic targets.Renal failure · 2026Review
- Gonadotropin-Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress-Induced Activation of the Locus Coeruleus-SAM Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Harmonic Analysis of Electrical Activity of the Autonomic Nervous System in Dorsal Perirenal Lumbar Regions in Healthy Volunteers and Patients with Arterial Hypertension.Bulletin of experimental biology and medicine · 2026Article
- Anticholinergic Burden and Progression to Kidney Replacement Therapy.Kidney international reports · 2026Article
- A Non-spinal Neural Circuit for Transmitting Information of Bladder Conditions.Neuroscience bulletin · 2026Article
- A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action.Comprehensive physiology · 2026Review
- Overcoming variable response in renal denervation: Key strategies for reliable clinical implementation.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Renal nerve stimulation modulates renal blood flow in a frequency-dependent manner.Bioelectronic medicine · 2025Article
- Cholinergic system in patients with chronic kidney disease: cognitive and renal implications.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Renal nerve stimulation modulates renal blood flow in a frequency-dependent manner.Research square · 2025Article
- Molecular and functional diversity of the autonomic nervous system.Nature reviews. Neuroscience · 2025Review
- Effects of renal denervation at BP-elevation/reduction sites guided by renal nerve stimulation on atrial neural and structural remodeling in a hypertensive canine model.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Direct vagal input to the gastrointestinal tract and other viscera: Re-definition of autonomic neuroscience or experimental artifacts?Autonomic neuroscience : basic & clinical · 2025Review
- Renal interoception: form, function, and open questions.Current opinion in neurobiology · 2025Review
- Aorticorenal ganglion ablation for blood pressure lowering in canine models.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined.Heart failure reviews · 2025Review
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Renal nerves in physiology, pathophysiology and interoception.Nature reviews. Nephrology · 2025Review
- Acute effects of Tai Chi with different practice emphasis on autonomic activity.Frontiers in sports and active living · 2025Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe kidneys critically contribute to body homeostasis under the control of the autonomic nerves, which enter the kidney along the renal vasculature. Although the renal sympathetic and sensory nerves have long been confirmed, no significant anatomic evidence exists for renal parasympathetic innervation.
methodsWe identified cholinergic nerve varicosities associated with the renal vasculature and pelvis using various anatomic research methods, including a genetically modified mouse model and immunostaining. Single-cell RNA sequencing (scRNA-Seq) was used to analyze the expression of
resultsWe found that cholinergic axons supply the main renal artery, segmental renal artery, and renal pelvis. On the renal artery, the newly discovered cholinergic nerve fibers are separated not only from the sympathetic nerves but also from the sensory nerves. We also found cholinergic ganglion cells within the renal nerve plexus. Moreover, the scRNA-Seq analysis suggested that acetylcholine receptors (AChRs) are expressed in the renal artery and its segmental branches. In addition, retrograde tracing suggested vagus afferents conduct the renal sensory pathway to the nucleus of the solitary tract (NTS), and vagus efferents project to the kidney.
conclusionsCholinergic nerves supply renal vasculature and renal pelvis, and a vagal brain-kidney axis is involved in renal innervation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.