Evidence map›Paper›PMID 36252038›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms.

Novalia Pishesha, Thibault Harmand, Claire Carpenet, Xin Liu, Atul Bhan, Ashraful Islam, Renate van den Doel, William Pinney, Hidde L Ploegh

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Sortase A Catalyzed Transpeptidation for Protein Bioengineering.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Novalia PisheshaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-8124-1265
Thibault HarmandProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Claire CarpenetProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Xin LiuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Atul BhanMassachusetts General Hospital, Boston, MA 02114.
Ashraful IslamProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Renate van den DoelProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
William PinneyProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
Hidde L PloeghProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-1090-6071
Boston Children's Hospital · USMassachusetts General Hospital · US

Funding

Non-invasive imaging of the anti-tumor immune responseR01CA255216 · NCI · BOSTON CHILDREN'S HOSPITAL · PI PISHESHA, NOVALIA · 2021 to 2025
$2.9M
NCI NIH HHS R01 CA255216NIH Director's Pioneer Award 1DP1AI150593-01
6 · The paper itself

Abstract

The distribution of Ly6C/G-positive cells in response to an infection of the mouse respiratory tract with influenza A virus was followed noninvasively over time by immuno-positron emission tomography. We converted nanobodies that recognize Ly6C and Ly6G, markers of neutrophils and other myeloid cells, as well as an influenza hemagglutinin-specific nanobody, into

Indexed as

Influenza, HumanSingle-Domain AntibodiesAdrenal Cortex HormonesAnimalsAnti-Inflammatory AgentsDexamethasoneHemagglutininsHumansInflammationMicePolyethylene GlycolsAdrenal Cortex HormonesAnti-Inflammatory AgentsDexamethasoneHemagglutininsPolyethylene GlycolsSingle-Domain Antibodiesdrug conjugatesinflammationnanobodyneutrophilsPET imaging

Identifiers

PMID36252038
PMCPMC9618054
OpenAlexW4306642893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.