ArticleProceedings of the National Academy of Sciences of the United States of America2022
Dynamic processing of hunger and thirst by common mesolimbic neural ensembles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Brain-wide mapping of acute hypoxia-induced neuronal activation in mice: A c-Fos immunofluorescence study.IBRO neuroscience reports · 2025Article
- Body fluid regulation.Current opinion in neurobiology · 2025Review
- Reward expectation and receipt differentially modulate the spiking of accumbens D1+ and D2+ neurons.Current biology : CB · 2025Article
- Article
- Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking.Nature communications · 2024Article
- Appetite Loss in Patients with Advanced Cancer Treated at an Acute Palliative Care Unit.Current oncology (Toronto, Ont.) · 2024Article
- A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis.Nature metabolism · 2024Article
- A Method for Evaluating Hunger and Thirst in Monkeys by Measuring Blood Ghrelin and Osmolality Levels.eNeuro · 2024Article
- Homeostatic feeding in hedonic centres.Nature metabolism · 2024Article
- Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need.Science (New York, N.Y.) · 2024Article
- An opponent striatal circuit for distributional reinforcement learning.bioRxiv : the preprint server for biology · 2024Article
- Linking drug and food addiction: an overview of the shared neural circuits and behavioral phenotype.Frontiers in behavioral neuroscience · 2023Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The nucleus accumbens (NAc) is a canonical reward center that regulates feeding and drinking but it is not known whether these behaviors are mediated by same or different neurons. We employed two-photon calcium imaging in awake, behaving mice and found that during the appetitive phase, both hunger and thirst are sensed by a nearly identical population of individual D1 and D2 neurons in the NAc that respond monophasically to food cues in fasted animals and water cues in dehydrated animals. During the consummatory phase, we identified three distinct neuronal clusters that are temporally correlated with action initiation, consumption, and cessation shared by feeding and drinking. These dynamic clusters also show a nearly complete overlap of individual D1 neurons and extensive overlap among D2 neurons. Modulating D1 and D2 neural activities revealed analogous effects on feeding versus drinking behaviors. In aggregate, these data show that a highly overlapping set of D1 and D2 neurons in NAc detect food and water reward and elicit concordant responses to hunger and thirst. These studies establish a general role of this mesolimbic pathway in mediating instinctive behaviors by controlling motivation-associated variables rather than conferring behavioral specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.