Evidence map›Paper›PMID 36252011›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice.

Juan Carlos De la Concepcion, Koki Fujisaki, Adam R Bentham, Neftaly Cruz Mireles, Victor Sanchez de Medina Hernandez, Motoki Shimizu, David M Lawson, Sophien Kamoun, Ryohei Terauchi, Mark J Banfield

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026
    Review
  4. Article
  5. Article
  6. Preassembly and independent trafficking of the exocyst complex inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. A century of advances in molecular genetics and breeding for sustainable resistance to rice blast disease.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. The exocyst in context.Biochemical Society transactions · 2024
    Review
  15. Fungal effectors: past, present, and future.Current opinion in microbiology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. The roles ofFrontiers in plant science · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Juan Carlos De la ConcepcionDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0002-7642-8375
Koki FujisakiDivision of Genomics and Breeding, Iwate Biotechnology Research Center, Iwate, 024-0003, Japan.ORCID 0000-0002-8247-6381
Adam R BenthamDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0001-5906-0962
Neftaly Cruz MirelesDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0003-1031-1470
Victor Sanchez de Medina HernandezDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0001-5320-6633
Motoki ShimizuDivision of Genomics and Breeding, Iwate Biotechnology Research Center, Iwate, 024-0003, Japan.ORCID 0000-0002-5622-5554
David M LawsonDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0002-7637-4303
Sophien KamounThe Sainsbury Laboratory, University of East Anglia, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0002-0290-0315
Ryohei TerauchiDivision of Genomics and Breeding, Iwate Biotechnology Research Center, Iwate, 024-0003, Japan.ORCID 0000-0002-0095-4651
Mark J BanfieldDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich, NR4 7UH, United Kingdom.ORCID 0000-0001-8921-3835
John Innes Centre · GBUniversity of North Carolina at Chapel Hill · USAustrian Academy of Sciences · ATUniversity of East Anglia · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/J/000CA523UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P012574UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/J/000PR9777UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/J/000PR9795UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V015508/1
6 · The paper itself

Abstract

Exocytosis plays an important role in plant-microbe interactions, in both pathogenesis and symbiosis. Exo70 proteins are integral components of the exocyst, an octameric complex that mediates tethering of vesicles to membranes in eukaryotes. Although plant Exo70s are known to be targeted by pathogen effectors, the underpinning molecular mechanisms and the impact of this interaction on infection are poorly understood. Here, we show the molecular basis of the association between the effector AVR-Pii of the blast fungus

Indexed as

MagnaportheOryzaDisease ResistanceFungal ProteinsHost-Pathogen InteractionsPlant DiseasesPlant ProteinsPlantsZincFungal ProteinsPlant ProteinsZinceffectorExocystNLRplant immunity

Identifiers

PMID36252011
PMCPMC9618136
OpenAlexW4306641915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.