Evidence map›Paper›PMID 36251776›Full record

ArticleDatabase : the journal of biological databases and curation2022

BRACS: A Dataset for BReAst Carcinoma Subtyping in H&E Histology Images.

Nadia Brancati, Anna Maria Anniciello, Pushpak Pati, Daniel Riccio, Giosuè Scognamiglio, Guillaume Jaume, Giuseppe De Pietro, Maurizio Di Bonito, Antonio Foncubierta, Gerardo Botti and 3 more

Abstract read
In one paragraph

Article in Database : the journal of biological databases and curation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nadia BrancatiInstitute for High Performance Computing and Networking of the Research Council of Italy, 111 Via Pietro Castellino, ICAR-CNR, Naples 80131, Italy.ORCID 0000-0001-9061-1187
Anna Maria AnnicielloNational Cancer Institute - IRCCS - Fondazione Pascale, 53 Via Mariano Semmola, Naples 80131, Italy.
Pushpak PatiIBM Research - Säumerstrasse 4, 8803 Rüschlikon, Zurich, Switzerland.
Daniel RiccioInstitute for High Performance Computing and Networking of the Research Council of Italy, 111 Via Pietro Castellino, ICAR-CNR, Naples 80131, Italy.
Giosuè ScognamiglioNational Cancer Institute - IRCCS - Fondazione Pascale, 53 Via Mariano Semmola, Naples 80131, Italy.
Guillaume JaumeIBM Research - Säumerstrasse 4, 8803 Rüschlikon, Zurich, Switzerland.
Giuseppe De PietroInstitute for High Performance Computing and Networking of the Research Council of Italy, 111 Via Pietro Castellino, ICAR-CNR, Naples 80131, Italy.
Maurizio Di BonitoNational Cancer Institute - IRCCS - Fondazione Pascale, 53 Via Mariano Semmola, Naples 80131, Italy.
Antonio FoncubiertaIBM Research - Säumerstrasse 4, 8803 Rüschlikon, Zurich, Switzerland.
Gerardo BottiNational Cancer Institute - IRCCS - Fondazione Pascale, 53 Via Mariano Semmola, Naples 80131, Italy.
Maria GabraniIBM Research - Säumerstrasse 4, 8803 Rüschlikon, Zurich, Switzerland.
Florinda FeroceNational Cancer Institute - IRCCS - Fondazione Pascale, 53 Via Mariano Semmola, Naples 80131, Italy.
Maria FrucciInstitute for High Performance Computing and Networking of the Research Council of Italy, 111 Via Pietro Castellino, ICAR-CNR, Naples 80131, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the most commonly diagnosed cancer and registers the highest number of deaths for women. Advances in diagnostic activities combined with large-scale screening policies have significantly lowered the mortality rates for breast cancer patients. However, the manual inspection of tissue slides by pathologists is cumbersome, time-consuming and is subject to significant inter- and intra-observer variability. Recently, the advent of whole-slide scanning systems has empowered the rapid digitization of pathology slides and enabled the development of Artificial Intelligence (AI)-assisted digital workflows. However, AI techniques, especially Deep Learning, require a large amount of high-quality annotated data to learn from. Constructing such task-specific datasets poses several challenges, such as data-acquisition level constraints, time-consuming and expensive annotations and anonymization of patient information. In this paper, we introduce the BReAst Carcinoma Subtyping (BRACS) dataset, a large cohort of annotated Hematoxylin and Eosin (H&E)-stained images to advance AI development in the automatic characterization of breast lesions. BRACS contains 547 Whole-Slide Images (WSIs) and 4539 Regions Of Interest (ROIs) extracted from the WSIs. Each WSI and respective ROIs are annotated by the consensus of three board-certified pathologists into different lesion categories. Specifically, BRACS includes three lesion types, i.e., benign, malignant and atypical, which are further subtyped into seven categories. It is, to the best of our knowledge, the largest annotated dataset for breast cancer subtyping both at WSI and ROI levels. Furthermore, by including the understudied atypical lesions, BRACS offers a unique opportunity for leveraging AI to better understand their characteristics. We encourage AI practitioners to develop and evaluate novel algorithms on the BRACS dataset to further breast cancer diagnosis and patient care. Database URL: https://www.bracs.icar.cnr.it/.

Indexed as

Artificial IntelligenceBreast NeoplasmsAlgorithmsEosine Yellowish-(YS)FemaleHematoxylinHumansEosine Yellowish-(YS)Hematoxylin

Identifiers

PMID36251776
PMCPMC9575967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.