Evidence map›Paper›PMID 36251576›Full record

ArticleNeurocase2022

Clinical, radiologic, and pathologic features of the globular glial tauopathy subtype of frontotemporal lobar degeneration in right temporal variant frontotemporal dementia with salient features of Geschwind syndrome.

Sylvia Josephy-Hernandez, Michael Brickhouse, Samantha Champion, David Dongkyung Kim, Alexandra Touroutoglou, Matthew Frosch, Bradford C Dickerson

Open access · greenAbstract readCase Reports
In one paragraph

Article in Neurocase, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sylvia Josephy-HernandezFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5447-1073
Michael BrickhouseFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Samantha ChampionForensic Pathology, Miami-Dade County Medical Examiner Office, Miami, FL, USA.
David Dongkyung KimDepartment of Psychiatry, Centre of Addiction and Mental Health & University of Toronto, Toronto, ON, Canada.
Alexandra TouroutoglouFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Matthew FroschNeuropathology Service, Department of Pathology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Bradford C DickersonFrontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Harvard University · USCentre for Addiction and Mental Health · CAMiami Dade College · US

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Imaging tau, amyloid, and neurodegeneration in PPAR01DC014296 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C, JOHNSON, KEITH A. · 2016 to 2020
$4.3M
Toward Personalized Prognosis and Outcomes in Primary Progressive AphasiaRF1NS131395 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI DICKERSON, BRADFORD C · 2023 to 2023
$2.5M
NIA NIH HHS P30 AG062421NIDCD NIH HHS R01 DC014296NINDS NIH HHS RF1 NS131395
6 · The paper itself

Abstract

Globular Glial Tauopathy (GGT) is a rare form of Frontotemporal Lobar Degeneration (FTLD) consisting of 4-repeat tau globular inclusions in astrocytes and oligodendrocytes. We present the pathological findings of GGT in a previously published case of a 73-year-old woman with behavioral symptoms concerning for right temporal variant frontotemporal dementia with initial and salient features of Geschwind syndrome. Clinically, she lacked motor abnormalities otherwise common in previously published GGT cases. Brain MRI showed focal right anterior temporal atrophy (indistinguishable from five FTLD-TDP cases) and subtle ipsilateral white matter signal abnormalities. Brain autopsy showed GGT type III and Alzheimer's neuropathologic changes. .

Indexed as

Frontotemporal DementiaFrontotemporal Lobar DegenerationPick Disease of the BrainTauopathiesAtrophyBrainFemaleHumanstau Proteinstau Proteinsfrontotemporal lobar degenerationGeschwind syndromeGGTGlobular glial tauopathy type IIIright temporal variant frontotemporal dementia

Identifiers

PMID36251576
PMCPMC9682487
OpenAlexW4306411630

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.