Evidence map›Paper›PMID 36251533›Full record

ArticleJournal of medical virology2023

Comparison of nucleocapsid and spike antibody ELISAs for determining SARS-CoV-2 seropositivity in Kenyan women and infants.

Carolyn S Fish, Prestone Owiti, Emily R Begnel, Hannah L Itell, Ednah Ojee, Judith Adhiambo, Vincent Ogweno, LaRinda A Holland, Barbra A Richardson, Adam K Khan and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Carolyn S FishDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Prestone OwitiDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Emily R BegnelDepartment of Global Health, Hans Rosling Center, University of Washington, Seattle, Washington, USA.
Hannah L ItellDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Ednah OjeeDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.ORCID 0000-0001-9730-5254
Judith AdhiamboDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Vincent OgwenoDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
LaRinda A HollandCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Barbra A RichardsonDepartment of Global Health, Hans Rosling Center, University of Washington, Seattle, Washington, USA.
Adam K KhanSchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.
Rabia MaqsoodCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Soren GanttDépartement de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHU St-Justine, Université de Montréal, Montréal, Québec, Canada.
Efrem S LimCenter for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Jennifer SlykerDepartment of Global Health, Hans Rosling Center, University of Washington, Seattle, Washington, USA.
John KinuthiaDepartment of Global Health, Hans Rosling Center, University of Washington, Seattle, Washington, USA.
Julie OverbaughDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Dalton WamalwaDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Dara A LehmanDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-0372-0631
Bhavna H ChohanDepartment of Global Health, Hans Rosling Center, University of Washington, Seattle, Washington, USA.
University of Washington · USUniversity of Nairobi · KEArizona State University · USFred Hutch Cancer Center · USUniversité de Montréal · CA

Funding

Comprehensive profiling of SARS-CoV-2 antibody responses and escape pathwaysR01AI138709 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OVERBAUGH, JULIE M. · 2018 to 2022
$5.0M
Maternal-infant Virome Transmission: the role of HIV and Antiretroviral TherapyR01HD092311 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LEHMAN, DARA ANN · 2017 to 2021
$3.9M
The Virome and Microbiome in Health and BK Disease of Kidney Transplant PatientsR00DK107923 · NIDDK · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIM, EFREM · 2017 to 2019
$747k
CIHRCIHR 201709CIHR 202005NIAID NIH HHS R01 AI138709NICHD NIH HHS R01 HD092311NIDDK NIH HHS R00 DK107923NIH HHS
6 · The paper itself

Abstract

A multitude of enzyme-linked immunosorbent assays (ELISAs) has been developed to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies since the coronavirus disease 2019 pandemic started in late 2019. Assessing the reliability of these assays in diverse global populations is critical. This study compares the use of the commercially available Platelia Total Ab Assay (Bio-Rad) nucleocapsid ELISA to the widely used Mount Sinai spike IgG ELISA in a Kenyan population seroprevalence study. Using longitudinal plasma specimens collected from a mother-infant cohort living in Nairobi, Kenya between May 2019 and December 2020, this study demonstrates that the two assays have a high qualitative agreement (92.7%) and strong correlation of antibody levels (R

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralEnzyme-Linked Immunosorbent AssayFemaleHumansInfantKenyaNucleocapsidReproducibility of ResultsSensitivity and SpecificitySeroepidemiologic StudiesSpike Glycoprotein, CoronavirusAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ELISAKenyanucleocapsidSARS-CoV-2serologyspike

Identifiers

PMID36251533
PMCPMC9839577
OpenAlexW4306412192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.