ArticleDiabetes care2022
Early-Onset Type 2 Diabetes and Mood, Anxiety, and Stress-Related Disorders: A Genetically Informative Register-Based Cohort Study.
Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Excess Burden of Inpatient Admissions and Emergency Department Visits Associated With Diabetes Across the Age Spectrum.Diabetes care · 2026Article
- Association between Early-Onset Metabolic Diseases and Adverse Mental Health Conditions: A Nationwide Cross-Sectional Study.Yonsei medical journal · 2026Article
- Association of triglyceride-glucose index with anxiety in first-episode, drug-naïve major depressive disorder: role of subclinical hypothyroidism.European archives of psychiatry and clinical neuroscience · 2026Article
- Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records.BMC medicine · 2026Article
- Stigma associated with early-onset type 2 diabetes: A secondary qualitative analysis.British journal of health psychology · 2026Article
- Psychological burden in Indian adults with type 2 diabetes: prevalence, overlap and predictors of diabetes distress, depression and anxiety - a cross-sectional study.BMJ public health · 2026Article
- Diabetic Cardiovascular Complications in Women and Young Adults.Current epidemiology reports · 2026Review
- Involvement of underserved 18-40 year olds living with early-onset type 2 diabetes in the M3 NIHR programme grant.Research involvement and engagement · 2025Article
- The role of continuous glucose monitoring (CGM) in psychiatric symptom management.CNS spectrums · 2025Review
- Young-onset type 2 diabetes-Epidemiology, pathophysiology, and management.Journal of diabetes investigation · 2025Review
- Ahmedabad declaration: A framework to combat growing epidemic of young-onset type 2 diabetes in Asia.Diabetes & metabolic syndrome · 2025Review
- Improvement in symptoms of anxiety and depression in individuals with type 2 diabetes: retrospective analysis of an intensive lifestyle modification program.BMC psychiatry · 2024Article
- Association of cardiometabolic multimorbidity with risk of late-life depression: a nationwide twin study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Association between age at diagnosis and all-cause mortality in type 2 diabetes: the Renal Insufficiency and Cardiovascular Events (RIACE) Italian Multicenter Study.Acta diabetologica · 2024Observational
- Glucagon-Like Peptide-1 Receptor Agonists and Risk for Suicidal Ideation and Behaviors in U.S. Older Adults With Type 2 Diabetes : A Target Trial Emulation Study.Annals of internal medicine · 2024Article
- Sex- and age-specific associations of serum essential elements with diabetes among the Chinese adults: a community-based cross-sectional study.Nutrition & metabolism · 2024Article
- Type 2 diabetes in children and adolescents: Exploring the disease heterogeneity and research gaps to optimum management.World journal of clinical pediatrics · 2024Review
- Changing landscape of diabetes in Asia - What are the unmet needs?Journal of diabetes investigation · 2024Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the association and familial coaggregation between early-onset type 2 diabetes (diagnosed before age 45 years) and mood, anxiety, and stress-related disorders and estimate the contribution of genetic and environmental factors to their co-occurrence. RESEARCH DESIGN AND
methodsThis population-based cohort study included individuals born in Sweden during 1968-1998, from whom pairs of full siblings, half-siblings, and cousins were identified. Information on diagnoses of early-onset type 2 diabetes and mood (including unipolar depression and bipolar disorder), anxiety, and stress-related disorders was obtained from the National Patient Register. Logistic and Cox regression models were used to assess the phenotypic association and familial coaggregation between type 2 diabetes and psychiatric disorders. Quantitative genetic modeling was conducted in full and maternal half-sibling pairs to estimate the relative contributions of genetic and environmental factors to the association.
resultsAmong a total of 3,061,192 individuals, 7,896 (0.3%) were diagnosed with early-onset type 2 diabetes. These individuals had higher risks of any diagnosis (odds ratio [OR] 3.62 [95% CI 3.44, 3.80]) and specific diagnosis of unipolar depression (3.97 [3.75, 4.22]), bipolar disorder (4.17 [3.68, 4.73]), anxiety (3.76 [3.54, 3.99]), and stress-related disorders (3.35 [3.11, 3.61]). Relatives of individuals with early-onset type 2 diabetes also had higher overall risks of the examined psychiatric disorders (ORs 1.03-1.57). These associations are largely explained by genetic factors (51-78%), with the rest explained by nonshared environmental factors.
conclusionsOur findings highlight the burden of mood, anxiety, and stress-related disorders in early-onset type 2 diabetes and demonstrate that shared familial liability may contribute to their co-occurrence, suggesting that in the future research investigators should aim to identify shared risk factors and ultimately refine preventive and intervention strategies.
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