Evidence map›Paper›PMID 36251222›Full record

ArticleDiscover oncology2022

Validation of the

Razan Zatarah, Nour Faqeer, Aseel Mahmoud, Tasnim Quraan, Lujain Matalka, Aya Kamal, Lama Nazer

Open access · goldAbstract read
In one paragraph

Article in Discover oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Razan ZatarahDepartment of Pharmacy, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan. RZ.12688@KHCC.JO.
Nour FaqeerDepartment of Pharmacy, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Aseel MahmoudDepartment of Pharmacy, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Tasnim QuraanDepartment of Pharmacy, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Lujain MatalkaDepartment of Pharmacy, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Aya KamalDepartment of Pharmacy, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
Lama NazerDepartment of Pharmacy, King Hussein Cancer Center, Queen Rania Street, Al-Jubeiha, P.O. Box 1269, Amman, 11941, Jordan.
King Hussein Cancer Center · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThough febrile neutropenia (FN) risk prediction models are important in clinical practice, their external validation is limited. In this study, we validated the Cycle-Specific Risk of FEbrile Neutropenia after ChEmotherapy (

methodsWe reviewed the medical records of patients with solid malignancies and diffuse large B-cell lymphoma during chemotherapy cycles 2-6 and recorded if patients developed FN, defined as absolute neutrophil counts less than 500 cells/microL with fever more than or equal to 38.2 ℃. The

resultsWe analyzed 2870 chemotherapy cycles, of which 42 (1.5%) were associated with FN. Among those, 3 (7.1%), 14 (33.3%), 5 (12%), and 20 (47.6%) were classified as low, intermediate, high, and very high risk for developing FN, respectively. The AUROCC was 0.72 (95% CI 0.64-0.81). Compared with the low risk group (n = 666), the IRR of developing FN was 1.01 (95% CI 0.15-43.37), 0.69 (95% CI 0.08-32.46) and 1.17 (95% CI 0.17-49.49) in the intermediate (n = 1431), high (n = 498) and very high (n = 275) risk groups, respectively.

conclusionThe

Indexed as

ChemotherapyChemotherapy-induced febrile neutropeniaFebrile neutropeniaNeoplasmsPrediction

Identifiers

PMID36251222
PMCPMC9576834
OpenAlexW4306407838

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.