Evidence map›Paper›PMID 36251161›Full record

ArticleJournal of the International AIDS Society2022

Facility-based HIV self-testing strategies may substantially and cost-effectively increase the number of men and youth tested for HIV in Malawi: results from an individual-based mathematical model.

Brooke E Nichols, Alexandra de Nooy, Mariet Benade, Kelvin Balakasi, Misheck Mphande, Gabriella Rao, Cassidy W Claassen, Shaukat Khan, Christian Stillson, Colin A Russell and 2 more

Abstract read
In one paragraph

Article in Journal of the International AIDS Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brooke E NicholsDepartment of Global Health, School of Public Health, Boston University, Boston, Massachusetts, USA.
Alexandra de NooyDepartment of Medical Microbiology, Amsterdam University Medical Centre, Amsterdam, the Netherlands.
Mariet BenadeDepartment of Global Health, School of Public Health, Boston University, Boston, Massachusetts, USA.
Kelvin BalakasiPartners in Hope, Lilongwe, Malawi.
Misheck MphandePartners in Hope, Lilongwe, Malawi.
Gabriella RaoTufts University, Boston, Massachusetts, USA.
Cassidy W ClaassenCenter for International Health, Education, and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shaukat KhanClinton Health Access Initiative, Boston, Maryland, USA.ORCID 0000-0001-7247-4190
Christian StillsonClinton Health Access Initiative, Boston, Maryland, USA.
Colin A RussellDepartment of Global Health, School of Public Health, Boston University, Boston, Massachusetts, USA.
Naoko DoiClinton Health Access Initiative, Boston, Maryland, USA.
Kathryn DovelRight to Care, Johannesburg, South Africa.ORCID 0000-0002-5622-3401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMalawi is rapidly closing the gap in achieving the UNAIDS 95-95-95 targets, with 90% of people living with HIV in Malawi aware of their status. As we approach epidemic control, interventions to improve coverage will become more costly. There is, therefore, an urgent need to identify innovative and low-cost strategies to maintain and increase testing coverage without diverting resources from other HIV services. The objective of this study is to model different combinations of facility-based HIV testing modalities and determine the most cost-effective strategy to increase the proportion of men and youth testing for HIV.

methodsA data-driven individual-based model was parameterized with data from a community-representative survey (socio-demographic, health service utilization and HIV testing history) of men and youth in Malawi (data collected August 2019). In total, 79 different strategies for the implementation of HIV self-testing (HIVST) and provider-initiated-testing-and-counselling at the outpatient department (OPD) were evaluated. Outcomes included percent of men/youth tested for HIV in a 12-month period, cost-effectiveness and human resource requirements. The testing yield was assumed to be constant across the scenarios.

resultsFacility-based HIVST offered year-round resulted in the greatest increase in the proportion of men and youth tested in the OPD (from 45% to 72%-83%), was considered cost-saving for HIVST kit priced at $1.00, and generally reduced required personnel as compared to the status quo. At higher HIVST kit prices, and more relaxed eligibility criteria, all scenarios that considered year-round HIVST in the OPD remained on the cost-effectiveness frontier.

conclusionsFacility-based HIVST is a cost-effective strategy to increase the proportion of men/youth tested for HIV in Malawi and decreases the human resource requirements for HIV testing in the OPD-providing additional healthcare worker time for other priority healthcare activities.

Indexed as

HIV InfectionsAdolescentHIV TestingHumansMalawiMaleMass ScreeningModels, TheoreticalSelf-Testingcost-effectiveness analysishealthcare facilitiesHIV self-testingmathematical modellingpriority populationssub-Saharan Africa

Identifiers

PMID36251161
PMCPMC9575938

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.