Evidence map›Paper›PMID 36251090›Full record

ArticleCellular and molecular life sciences : CMLS2022

A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR.

Chiu-Yueh Hung, Chuanshu Zhu, Farooqahmed S Kittur, Maotao He, Erland Arning, Jianhui Zhang, Asia J Johnson, Gurpreet S Jawa, Michelle D Thomas, Tomas T Ding and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chiu-Yueh Hung *Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Chuanshu Zhu *Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Farooqahmed S Kittur *Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Maotao He *Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Erland Arning *Baylor Scott and White Research Institute, Institute of Metabolic Disease, Dallas, TX, 75204, USA.
Jianhui ZhangDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Asia J JohnsonDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Gurpreet S JawaDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Michelle D ThomasDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA.
Tomas T DingDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA. tding@nccu.edu.
Jiahua XieDepartment of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA. jxie@nccu.edu.ORCID http://orcid.org/0000-0003-2786-0281
North Carolina Central University · USBaylor Medical Center at Garland · USUniversity of North Carolina at Chapel Hill · USWeifang Medical University · CN

Funding

In Vivo Neuroprotective Properties and Action Mechanism(s) of Plant-produced Asialo-erythropoietinSC1GM111178 · NIGMS · NORTH CAROLINA CENTRAL UNIVERSITY · PI XIE, JIAHUA · 2017 to 2024
$2.9M
China Scholarship Council 201306305041NIGMS NIH HHS SC1 GM111178NIGMS NIH HHS SC1GM111178
6 · The paper itself

Abstract

Pathophysiology associated with Huntington's disease (HD) has been studied extensively in various cell and animal models since the 1993 discovery of the mutant huntingtin (mHtt) with abnormally expanded polyglutamine (polyQ) tracts as the causative factor. However, the sequence of early pathophysiological events leading to HD still remains elusive. To gain new insights into the early polyQ-induced pathogenic events, we expressed Htt exon1 (Htt

Indexed as

GTP CyclohydrolaseHuntington DiseasePlants, Genetically ModifiedAnimalsCarbonFolic AcidHuntingtin ProteinMiceProtein AggregatesProteomicsTetrahydrofolate DehydrogenaseCarbonFolic AcidGTP CyclohydrolaseHuntingtin ProteinProtein AggregatesTetrahydrofolate DehydrogenaseDihydrofolate reductaseGTP cyclohydrolase IHuntington’s diseaseOne-carbon metabolismProtein aggregationQuantitative proteomic analysisTetrahydrobiopterin biosynthesis

Identifiers

PMID36251090
PMCPMC9576654
OpenAlexW4306382268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.