SynthesisPflugers Archiv : European journal of physiology2022
Acute and chronic effects of physical exercise on IgA and IgG levels and susceptibility to upper respiratory tract infections: a systematic review and meta-analysis.
Synthesis in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Prepandemic Physical Activity and Risk of COVID-19 Diagnosis and Hospitalization in Older Adults.JAMA network open · 2024Trial
- Use ofFrontiers in immunology · 2023Trial
- Review
- Salivary IgA and dentine caries in relation to physical activity and fitness: A cohort-based cross-sectional study.Clinical oral investigations · 2026Article
- Does body composition influence air force pilots' resistance to high-G acceleration? A systematic review meta-analysis.iScience · 2026Article
- The Immune System as a Biosensor of Health and Athletic Performance.Scandinavian journal of medicine & science in sports · 2026Review
- COVID-19 vaccination in relation to immune response and physical activity levels.Frontiers in public health · 2026Article
- The influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19.Immunity & ageing : I & A · 2025Review
- Effect of a 12-Week Multicomponent Program on Mental Disorders as Well as Biochemical and Immunological Parameters in Teachers with Overweight.Biomedicines · 2025Article
- Beyond physical exhaustion: Understanding overtraining syndrome through the lens of molecular mechanisms and clinical manifestation.Sports medicine and health science · 2025Review
- Alcohol consumption and childhood trauma impact serum immunoglobulin levels in patients with alcohol use disorder.Alcohol, clinical & experimental research · 2025Article
- Assessment of the prevalence of respiratory pathogens and the level of immunity to respiratory viruses in soldiers and civilian military employees in Poland.Respiratory research · 2025Article
- The Effect of Exercise on Immune Response in Population with Increased Risk Factors for Cardiovascular Disease: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2024Review
- Review
- Demystifying roles of exercise in immune response regulation against acute respiratory infections: A narrative review.Sports medicine and health science · 2024Review
- Review
- Understanding the dynamics of inflammatory mediators in response to mind-body movement therapies (MBMTs): A systematic review and meta-analysis of studies in healthy subjects.Brain behavior and immunity integrative · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis aimed at evaluating acute and chronic effects of physical exercise on IgA and IgG levels, as well as its relationship with the susceptibility to develop upper respiratory tract infections (URTI). This systematic review and meta-analysis was conducted and reported in accordance with PRISMA statement. A systematic search of PubMed, Web of Science, and EMBASE was performed in July 2020. This systematic review and meta-analysis included studies in which participants performed acute exercise or chronic physical training and were subjected to analyses of URTI incidence and concentrations of IgA and IgG. The selected studies for systematic review were divided into the following three groups: (I) trials that evaluated the effects of acute exercise in sedentary subjects, (II) trials that evaluated the effects of acute exercise in athletes/trained individuals, and (III) trials that evaluated the effects of chronic physical training on the incidence of URTI, as well as on the levels of IgA and IgG. Acute exercise increases the IgA levels in trained subjects but does not affect its levels in untrained subjects. Such increase in IgA levels induced by acute exercise is greater in trained individual that performed ultramarathon. On the other hand, chronic physical training reduces IgA levels in both trained and untrained subjects, does not change IgA levels in non-military subjects, besides from not affecting IgG levels. The present systematic review and meta-analysis indicates that acute exercise positively influences IgA levels in trained individuals, being this effect pronounced when a strenuous exercise such as ultramarathon is executed. Chronic physical training, in turn, does not affect IgG levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.