ArticleProteins2023
Interplay between hydrogen and chalcogen bonds in cysteine.
Article in Proteins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Cysteine-mediated structural stabilization of the tetrameric GlpF.European biophysics journal : EBJ · 2026Article
- Comparative evaluation of E. coli expression systems for soluble hScFv-IL-17A with an unpaired CDR-L3 cysteine.Journal, genetic engineering & biotechnology · 2025Article
- Synergistic Interplay between Intermolecular Halogen and Chalcogen Bonds in the Dihalogen Adducts of 2,5-Bis(pyridine-2-yl)tellurophene: Reactivity Insights and Structural Trends.Inorganic chemistry · 2025Article
- Self-contacting Cys, Ser, and Thr residues in high-resolution protein crystal structures: Tertiary constraints or hydrogen bonds?Protein science : a publication of the Protein Society · 2024Article
- On the Importance of Halogen and Chalcogen Bonds in the Solid State of Nucleic Acids: A Combined Crystallographic and Theoretical Perspective.International journal of molecular sciences · 2023Article
- Interplay between hydrogen and chalcogen bonds in cysteine.Proteins · 2023Article
- Automated identification of chalcogen bonds in AlphaFold protein structure database files: is it possible?Frontiers in molecular biosciences · 2023Article
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein structures are stabilized by several types of chemical interactions between amino acids, which can compete with each other. This is the case of chalcogen and hydrogen bonds formed by the thiol group of cysteine, which can form three hydrogen bonds with one hydrogen acceptor and two hydrogen donors and a chalcogen bond with a nucleophile along the extension of the CS bond. A survey of the Protein Data Bank shows that hydrogen bonds are about 40-50 more common than chalcogen bonds, suggesting that they are stronger and, consequently, prevail, though not always. It is also observed that frequently a thiol group that forms a chalcogen bond is also involved, as a hydrogen donor, in a hydrogen bond.
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