Evidence map›Paper›PMID 36250805›Full record

ArticleAngewandte Chemie (International ed. in English)2022

A Vitamin B

Oliver J Knowles, Linus O Johannissen, Giacomo E M Crisenza, Sam Hay, David Leys, David J Procter

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 39 citations in OpenAlex.

  1. B(COrganic letters · 2026
    Article
  2. Article
  3. Chemical Tagging ofJournal of the American Chemical Society · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Vitamin BAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  9. A Vitamin BAngewandte Chemie (International ed. in English) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Oliver J KnowlesDepartment of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.ORCID 0000-0002-0759-2702
Linus O JohannissenManchester Institute of Biotechnology and Department of Chemistry, University of Manchester, Princess Street, Manchester, M1 7DN, UK.
Giacomo E M CrisenzaDepartment of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.ORCID 0000-0003-0622-2862
Sam HayManchester Institute of Biotechnology and Department of Chemistry, University of Manchester, Princess Street, Manchester, M1 7DN, UK.ORCID 0000-0003-3274-0938
David LeysManchester Institute of Biotechnology and Department of Chemistry, University of Manchester, Princess Street, Manchester, M1 7DN, UK.ORCID 0000-0003-4845-8443
David J ProcterDepartment of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.ORCID 0000-0003-3179-2509
University of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S003320/1
6 · The paper itself

Abstract

Access to new non-canonical amino acid residues is crucial for medicinal chemistry and chemical biology. Analogues of the amino acid methionine have been far less explored-despite their use in biochemistry, pharmacology and peptide bioconjugation. This is largely due to limited synthetic access. Herein, we exploit a new disconnection to access non-natural methionines through the development of a photochemical method for the radical α-C-H functionalization of sulfides with alkenes, in water, using inexpensive and commercially-available riboflavin (vitamin B

Indexed as

MethionineRiboflavinAmino AcidsCatalysisPeptidesRacemethionineVitaminsAmino AcidsMethioninePeptidesRacemethionineRiboflavinVitaminsamino acidsflavinsmethioninephotocatalysissulfides

Identifiers

PMID36250805
PMCPMC10100050
OpenAlexW4306407977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.