Evidence map›Paper›PMID 36250682›Full record

ArticleJournal of veterinary internal medicine2022

Nasal transmission of equine parvovirus hepatitis.

Joy E Tomlinson, Gerlinde R Van de Walle

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Nasal transmission of equine parvovirus hepatitis.Journal of veterinary internal medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joy E TomlinsonBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID https://orcid.org/0000-0001-7365-3967
Gerlinde R Van de WalleBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID https://orcid.org/0000-0002-2064-8029
Cornell University · US

Funding

Comparative Animal Models of Viral HepatitisK08AI141767 · NIAID · CORNELL UNIVERSITY · PI TOMLINSON, JOY E · 2019 to 2023
$699k
National Institute of Allergy and Infectious Diseases K08AI141767National Institute of Food and Agriculture 2020-67015-31297NIAID NIH HHS K08 AI141767
6 · The paper itself

Abstract

backgroundEquine parvovirus hepatitis (EqPV-H) is highly prevalent and causes subclinical to fatal hepatitis, which can occur in outbreaks. Whereas iatrogenic transmission is well documented, the mode of horizontal transmission is not known. The virus is shed in nasal, oral and fecal secretions, and PO transmission has been reported in a single horse. HYPOTHESIS/

objectiveInvestigate the efficiency of PO and nasal transmission of EqPV-H in a larger cohort.

methodsProspective experimental transmission study. Eleven EqPV-H-negative horses were inoculated with 5 × 10

resultsNo horse became viremic or seroconverted within 8 weeks after PO inoculation. After intranasal inoculation, 5 horses became viremic within 6 to 12 weeks and seroconverted within 10 to 19 weeks. After a period without monitoring from 12 to 19 weeks postinoculation, another 5 horses were found to be viremic at 19 to 22 weeks. The second set of 5 horses could have been infected by horizontal transmission from the first 5 because of cohousing. CONCLUSIONS AND CLINICAL IMPORTANCE: We demonstrated that EqPV-H can be transmitted nasally. The prolonged eclipse phase before detectable viremia indicates biosecurity measures to control spread could be impractical.

Indexed as

HepatitisHepatitis, Viral, AnimalHorse DiseasesParvoviridae InfectionsParvovirusAnimalsHorsesProspective StudiesbiosecurityintranasaloralTheiler's disease

Identifiers

PMID36250682
PMCPMC9708389
OpenAlexW4306407043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.