ArticleJournal of the American Heart Association2022
Associations of Hypertriglyceridemia Onset Age With Cardiovascular Disease and All-Cause Mortality in Adults: A Cohort Study.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Efficacy and safety of small interfering RNA (siRNA) therapies for hypertriglyceridemia and mixed dyslipidemia: an updated systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Association of fenofibrate therapy with cardiovascular events and mortality in diabetes patients with early-diagnosed hyperlipidemia.Lipids in health and disease · 2026 · on this mapTrial
- Serum Atherogenic Index and Cardiovascular Risk in Young Adults: From Early Detection to Preventive Action.JACC. Asia · 2026Article
- Association of the atherogenic index of plasma combined with obesity indices with cardiovascular disease and mortality.Lipids in health and disease · 2026Article
- The transition from preclinical to clinical obesity: the importance of a borderline stage.Clinical science (London, England : 1979) · 2026Review
- Association of the triglyceride-glucose index with blood pressure and hypertension in a large adult population: A cross-sectional study.SAGE open medicine · 2026Article
- Current status of premature myocardial infarction research in China: a systematic review and international comparative perspective.Frontiers in cardiovascular medicine · 2026Review
- Efficacy and safety of guanxinshutong capsule as adjunctive therapy for unstable angina: an integrated systematic review, meta-analysis, and network pharmacology study.Frontiers in cardiovascular medicine · 2026Review
- A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine.Scientific reports · 2025Article
- Association between atherogenic index of plasma (AIP) and all-cause and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD): a cohort study based on NHANES 1999-2018.Cardiovascular diabetology · 2025Article
- Association between pan-immune-inflammation value and dyslipidemia in the United States population.Frontiers in endocrinology · 2025Article
- Association between cardiometabolic index and all-cause and cause-specific mortality among the general population: NHANES 1999-2018.Lipids in health and disease · 2024Article
- Association between the atherogenic index of plasma trajectory and risk of heart failure among hypertensive patients: a prospective cohort study.Cardiovascular diabetology · 2024Article
- Geriatric nutrition risk index in the prediction of all-cause and cardiovascular mortality in older adults with hyperlipidemia: NHANES 1999-2018.BMC geriatrics · 2024Article
- Article
- Prevalence of dyslipidemia and associated factors in sedentary occupational population from Shanghai: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2024Article
- Multi-trajectories of triglyceride-glucose index and lifestyle with Cardiovascular Disease: a cohort study.Cardiovascular diabetology · 2023Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Limited studies have involved new-onset hypertriglyceridemia, and this study was to evaluate the associations of hypertriglyceridemia onset age with cardiovascular diseases (CVD) and all-cause mortality. Methods and Results This population-based prospective study enrolled 98 779 participants free of hypertriglyceridemia and CVD at baseline in the Kailuan study initiated in June 2006. All participants underwent health checkups biennially until December 2017, and a total of 13 832 participants developed new hypertriglyceridemia. A 1:1 age- (±1 year) and sex-matched analysis was applied to select control subject of the same year for each new-onset case. There were 13 056 case-control pairs included. The total follow-up time was 179 409 person-years, with a median follow-up time of 7.0 years. Primary outcomes were CVD and all-cause mortality, and hazard ratios were estimated after adjustment for baseline characteristics. A total of 807 incident CVD events and 600 all-cause mortality events were documented. After multivariable adjustment, participants with hypertriglyceridemia onset age <45 years had the highest risk compared with matched controls, with hazard ratios of 2.61 (95% CI, 1.59-4.27) for CVD, 4.69 (95% CI, 2.34-9.40) for all-cause mortality, 2.23 (95% CI, 0.67-7.38) for myocardial infarction, and 2.68 (95% CI, 1.56-4.62) for stroke. The risk estimates gradually decreased with each decade increase in the onset age of hypertriglyceridemia. Conclusions Among Chinese adults, hypertriglyceridemia identified at an earlier onset age was associated with higher risks for CVD and all-cause mortality.
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