Evidence map›Paper›PMID 36250635›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

Selective reduction of neurotransmitter release by cAMP-dependent pathways in mouse detrusor.

Basu Chakrabarty, Marcus J Drake, Anthony J Kanai, Christopher H Fry

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Basu ChakrabartySchool of Physiology, Pharmacology, and Neuroscience, https://ror.org/0524sp257University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-7320-4931
Marcus J DrakeSchool of Physiology, Pharmacology, and Neuroscience, https://ror.org/0524sp257University of Bristol, Bristol, United Kingdom.
Anthony J KanaiDepartments of Medicine and Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-4780-7592
Christopher H FrySchool of Physiology, Pharmacology, and Neuroscience, https://ror.org/0524sp257University of Bristol, Bristol, United Kingdom.ORCID 0000-0003-3647-5983
University of Bristol · GBSouthmead Hospital · GBUniversity of Pittsburgh · US

Funding

PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse BladdersR01DK098361 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A, KANAI, ANTHONY JOHN · 2014 to 2024
$5.7M
NIDDK NIH HHS R01 DK098361
6 · The paper itself

Abstract

Parasympathetic nerve-mediated contractions of detrusor smooth muscle are generated by ATP and acetylcholine (ACh) release from efferent nerve terminals. In humans, ACh is responsible for detrusor contractions in normal human bladders, whereas ATP has an additional role in overactive bladder pathologies. The ATP metabolite, adenosine, relaxes nerve-mediated contractions, with a potential action via presynaptic adenosine A

Indexed as

Urinary Bladder, OveractiveAcetylcholineAdenosineAdenosine TriphosphateAnimalsCyclic AMPElectric StimulationHumansMaleMiceMice, Inbred C57BLMuscle ContractionNeurotransmitter AgentsReceptors, Purinergic P1AcetylcholineAdenosineAdenosine TriphosphateCyclic AMPNeurotransmitter AgentsReceptors, Purinergic P1adenosineadenosine triphosphatecyclic adenosine monophosphatedetrusor smooth muscleneurotransmitter release

Identifiers

PMID36250635
PMCPMC9678420
OpenAlexW4306406812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.