Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023
One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Exercise modalities and dose for improving arterial stiffness in risk-enriched adults: a systematic review and dose-response network meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Comparative effectiveness of exercise modalities and doses on carotid-femoral pulse wave velocity in adults: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2026Pooled it
- Comparative effects of different exercise modalities on cognitive domains in older adults: a Bayesian network meta-analysis and meta-regression.Frontiers in nutrition · 2026Pooled it
- Comparative effects of ball sports on executive function subdomains in children and adolescents: a network meta-analysis.Frontiers in psychology · 2026Pooled it
- Exercise Training Reduces Cerebrovascular Impedance in Patients with Amnestic Mild Cognitive Impairment: A 1-Year Randomized Controlled Trial.Medicine and science in sports and exercise · 2026Trial
- A multi-modal medical management and lifestyle intervention increase cerebral blood flow and lowers diabetic risk in persons with early Alzheimer's disease: Mid-trial results from the PREVENTION trial.Journal of Alzheimer's disease : JAD · 2025Trial
- Intermittent hypoxia training improves cerebral blood flow without cognitive impairment.Annals of clinical and translational neurology · 2025Trial
- Effects of Physical Activity on Brain White Matter Integrity Are Region-, Dose-, and Age-Dependent: Findings From the Population-Based Rhineland Study.Aging cell · 2026Article
- Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.Aging and health research · 2026Article
- Sleep Disorders and Cognitive Function in Multiple Sclerosis: A Systematic Review of Polysomnographic Studies and Implications for Neurorehabilitation Strategies.Life (Basel, Switzerland) · 2026Review
- Relationship Between Degree of Stenosis and Time-to-Peak Delay in High Grade Asymptomatic Carotid Artery Disease.Stroke · 2026Article
- Effect of a single exercise bout on fasting cerebral blood flow and brain insulin sensitivity in middle-aged to older adults.Experimental physiology · 2026Article
- Cerebral blood flow regulation, central arterial stiffness and traumatic brain injury: Effects of aerobic exercise training.Experimental physiology · 2026Review
- Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026Review
- Cognitive Processing Efficiency (Throughput) Improves with Aerobic Exercise and Is Independent of the Environmental Oxygenation Level: A Randomized Crossover Trial.Sports (Basel, Switzerland) · 2026Article
- Exercise snacks and cognitive health in older adults: mechanisms, implementation, and public health relevance.Frontiers in public health · 2026Review
- Adolescent sports participation and school adjustment: the chain-mediation roles of peer relationships and depressive symptoms.Frontiers in public health · 2026Article
- Physical activity and exercise in dementia: clinical relevance and emerging insights.Frontiers in dementia · 2026Review
- Muscle and mind: rewiring cognitive-motor recovery through exercise-responsive neurophysiology in neurological populations.Frontiers in psychology · 2026Review
- Effects of Prior Exercise Habits and Adherence on Cognitive Function, Physical Fitness, and Vascular Health in Older Adults: An Exploratory Exercise-Based Intervention Trial.Dementia and neurocognitive disorders · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
The impact of aerobic exercise training (AET) on cerebral blood flow (CBF) regulation remains inconclusive. This study investigated the effects of one-year progressive, moderate-to-vigorous AET on CBF, central arterial stiffness, and cognitive performance in cognitively normal older adults. Seventy-three older adults were randomly assigned to AET or stretching-and-toning (SAT, active control) intervention. CBF was measured with 2D duplex ultrasonography. Central arterial stiffness, measured by carotid β-stiffness index, was assessed with the ultrasonography and applanation tonometry. Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by CBF. A cognitive battery was administered with a focus on memory and executive function. Cardiorespiratory fitness was measured by peak oxygen consumption (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.