Evidence map›Paper›PMID 36250371›Full record

ArticleJournal of neurogastroenterology and motility2022

Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial.

Seung Yong Shin, Sein Park, Jung Min Moon, Kisung Kim, Jeong Wook Kim, Jongsik Chun, Tae Hee Lee, Chang Hwan Choi, Microbiome Research Group of the Korean Society for Neurogastroenterology and Motility

Erratum issuedAbstract read
In one paragraph

Article in Journal of neurogastroenterology and motility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  8. The gut microbiome connects nutrition and human health.Nature reviews. Gastroenterology & hepatology · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Seung Yong ShinChung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea.
Sein ParkInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea.
Jung Min MoonChung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea.
Kisung KimChung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea.
Jeong Wook KimChung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea.
Jongsik ChunInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea.
Tae Hee LeeInstitute for Digestive Research, Digestive Disease Center Soonchunhyang University College of Medicine, Seoul, Korea.
Chang Hwan ChoiChung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea.
Microbiome Research Group of the Korean Society for Neurogastroenterology and Motility

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: We aim to evaluate the differences in the microbiome of responders and non-responders, as well as predict the response to probiotic therapy, based on fecal microbiome data in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Methods: A multi-strain probiotics that contains Results: There was no significant difference in the alpha and beta diversity between the responder and non-responder groups. The abundances of the phylum Proteobacteria and genus Conclusions: Probiotic treatment changes some composition of fecal bacteria in patients with IBS-D.

Indexed as

BiomarkersIrritable bowel syndromeMicrobiotaPredictionProbiotics

Identifiers

PMID36250371
PMCPMC9577570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.