Evidence map›Paper›PMID 36250285›Full record

Observational studyHead & neck2023

The role of adjuvant therapy in pT4N0 laryngectomized patients: Multicentric observational study.

Francesco Mattioli, Edoardo Serafini, Alfredo Lo Manto, Francesca Mularoni, Andi Abeshi, Marco Lionello, Marco Ferrari, Alberto Paderno, Davide Lancini, Davide Mattavelli and 20 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Head & neck, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Adjuvant radiotherapy in pT3 glottic squamous cell carcinoma: an unnecessary burden?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Optimising oncologic outcomes in pT3 glottic cancers treated by transoral laser microsurgery: the impact of adjuvant treatment.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Article
  4. Article
  5. Survival analysis of laryngeal squamous cell cancer, considering different treatment modalities and other factors influencing survival - a monocentric retrospective investigation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  6. Influential Factors on Survival in Laryngeal Cancer and Treatment Modalities Comparison.ORL; journal for oto-rhino-laryngology and its related specialties · 2025
    Article
  7. The role of central neck dissection and adjuvant treatment in pT4aN0 laryngeal carcinoma treated with open partial horizontal laryngectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 11 institutions in 1 country.

Francesco MattioliDepartment of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Edoardo SerafiniDepartment of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Alfredo Lo MantoDepartment of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.ORCID https://orcid.org/0000-0002-2928-2051
Francesca MularoniSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padua - Azienda Ospedale Università di Padova, Padua, Italy.
Andi AbeshiDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Marco LionelloOtorhinolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
Marco FerrariSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padua - Azienda Ospedale Università di Padova, Padua, Italy.
Alberto PadernoUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Davide LanciniUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Davide MattavelliUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0001-7023-6746
Gennaro ConfuortoOtolaryngology Unit, Department of Surgery, Dentistry and Paediatrics, University of Verona, Verona, Italy.
Filippo MarchiDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID https://orcid.org/0000-0002-7997-964X
Alessandro IoppiDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Claudio SampieriDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giuseppe MercanteOtorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Armando De VirgilioOtorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID https://orcid.org/0000-0003-0738-8223
Gerardo PetruzziDepartment of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.ORCID https://orcid.org/0000-0003-0371-7667
Erika CrosettiENT Unit, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital Orbassano, Turin, Italy.ORCID https://orcid.org/0000-0003-4340-9677
Raul PelliniDepartment of Otolaryngology - Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Spriano GiuseppeOtorhinolaryngology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Peretti GiorgioDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Cesare PiazzaUnit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-2391-9357
Gabriele MolteniOtolaryngology Unit, Department of Surgery, Dentistry and Paediatrics, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-7764-2122
Andy BertolinOtorhinolaryngology Unit, Vittorio Veneto Hospital, Vittorio Veneto, Italy.
Giovanni SuccoENT Unit, San Giovanni Bosco Hospital, Turin, Italy.ORCID https://orcid.org/0000-0003-0375-6623
Piero NicolaiSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padua - Azienda Ospedale Università di Padova, Padua, Italy.
Matteo Alicandri-CiufelliDepartment of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Daniele MarchioniDepartment of Otorhinolaryngology - Head and Neck Surgery, University Hospital of Modena, Modena, Italy.
Livio PresuttiDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Matteo FermiDepartment of Otorhinolaryngology - Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.ORCID https://orcid.org/0000-0002-2727-0321
University of Modena and Reggio Emilia · ITOspedale Policlinico San Martino · ITUniversity of Brescia · ITHumanitas University · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Padua · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Civile di Vittorio Veneto · ITUniversity of Verona · ITOspedale San Giovanni Bosco · ITOspedale San Luigi Gonzaga · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo retrospectively evaluate oncological outcomes in two groups of patients with pT4aN0 glottic SCC treated with total laryngectomy (TL) and neck dissection (ND) who underwent postoperative radiotherapy or exclusive clinical and radiological follow-up.

methodsIt includes patients with pT4N0 glottic SCC who underwent TL and unilateral or bilateral ND with or without PORT. Divided in two comparison groups: the first group underwent adjuvant RT (TL-PORT); the second group referred to clinical and radiological follow-up (TL).

resultsPORT was associated with a better OS while no differences were found in terms of DSS. A better local control is achieved when PORT is administered while no differences in terms of regional and distant control rates were found. Bilateral ND positively impacts on the regional control while the PNI negatively impact the regional control.

conclusionsA tailored PORT protocol might be considered for pT4N0 glottic SCC treated with TL and ND, both considering the ND's extent and presence of PNI.

Indexed as

Carcinoma, Squamous CellLaryngeal NeoplasmsGlottisHumansLaryngectomyNeck DissectionNeoplasm Recurrence, LocalNeoplasm StagingRetrospective Studiesglottishead and neck neoplasmslaryngeal neoplasmslaryngectomyradiotherapysquamous cell carcinoma of head and neck

Identifiers

PMID36250285
PMCPMC10092371
OpenAlexW4306399363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.