Evidence map›Paper›PMID 36250267›Full record

ReviewJournal of cell science2023

Go with the flow - bulk transport by molecular motors.

Wen Lu, Vladimir I Gelfand

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of cell science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  5. Article
  6. Review
  7. Roles of molecular motors in insulin-secreting beta cells.Current opinion in cell biology · 2025
    Review
  8. Active nematic pumps.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. CaCurrent biology : CB · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Flow, sense and divide.Nature cell biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Cytoplasmic stirring by active carpets.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wen LuDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA.ORCID 0000-0002-8849-8100
Vladimir I GelfandDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611-3008, USA.ORCID 0000-0002-6361-2798
Northwestern University · US

Funding

Structural basis of the specific protein-protein interactions underlying IF assemP01GM096971 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDMAN, ROBERT D · 2011 to 2021
$16.8M
Microtubule motors, cytoskeletal organization and cell polarityR35GM131752 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Vladimir I Gelfand · 2019 to 2026
$6.4M
NIGMS NIH HHS P01 GM096971NIGMS NIH HHS R35 GM131752
6 · The paper itself

Abstract

Cells are the smallest building blocks of all living eukaryotic organisms, usually ranging from a couple of micrometers (for example, platelets) to hundreds of micrometers (for example, neurons and oocytes) in size. In eukaryotic cells that are more than 100 µm in diameter, very often a self-organized large-scale movement of cytoplasmic contents, known as cytoplasmic streaming, occurs to compensate for the physical constraints of large cells. In this Review, we discuss cytoplasmic streaming in multiple cell types and the mechanisms driving this event. We particularly focus on the molecular motors responsible for cytoplasmic movements and the biological roles of cytoplasmic streaming in cells. Finally, we describe bulk intercellular flow that transports cytoplasmic materials to the oocyte from its sister germline cells to drive rapid oocyte growth.

Indexed as

Drosophila ProteinsKinesinsBiological TransportCytoplasmic StreamingDyneinsMicrotubulesOogenesisDrosophila ProteinsDyneinsKinesinsActinCytoplasmic streamingDyneinKinesinMicrotubulesMyosin

Identifiers

PMID36250267
PMCPMC10755412
OpenAlexW4306391961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.