Evidence map›Paper›PMID 36250247›Full record

ArticleCartilage2022

Anti-Inflammatory and Chondro-Protective Effects of Acidic Polysaccharide from Enteromorpha Prolifera in Experimental Models of Osteoarthritis

Chih-Chien Wang, Jeng-Wei Lu, Kuang-Hsing Chiang, Yu-Shuan Cheng, You-Hsiang Chu, Yi-Jen Peng, Chia-Hui Cheng, Chia-Yu Chang, Jiunn-Jye Chuu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Frontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Chih-Chien WangDepartment of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Jeng-Wei LuAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore.ORCID 0000-0003-2128-2046
Kuang-Hsing ChiangTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan.
Yu-Shuan ChengDepartment of Biotechnology and Food Technology, College of Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
You-Hsiang ChuGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Yi-Jen PengDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chia-Hui ChengDepartment of Biotechnology and Food Technology, College of Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
Chia-Yu ChangDepartment of Neurology, Chi Mei Medical Center, Tainan, Taiwan.
Jiunn-Jye ChuuDepartment of Biotechnology and Food Technology, College of Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan.
Southern Taiwan University of Science and Technology · TWTri-Service General Hospital · TWChi Mei Medical Center · TWNational Defense Medical Center · TWNational Taiwan University · TWSingapore-MIT Alliance for Research and Technology · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOsteoarthritis (OA) progression has been shown to increase the expression of inflammatory cytokines in joints, leading to the destruction of cartilage matrix. Interleukin (IL)-1β is a potent inflammatory cytokine associated with osteoarthritic synovial fluid. The protective effects of polysaccharides from Enteromorpha prolifera against acute hepatic injury was reported.

designIn this study, we examined the effects of Enteromorpha polysaccharide extracts (EPEs) in the treatment of OA. The effects of the EPEs were assessed using an IL-1β-stimulated SW1353 and SW982 cells. The expression levels of specific mRNA and proteins were evaluated using semi-quantitative reverse transcription polymerase chain reaction (sqRT-PCR) and western immunoblotting. An OA animal study involving C57BL/6J mice was also conducted to assess the effects on tactile sensitivity and anterior cruciate ligament transection (ACLT).

resultsAcidic polysaccharide extract (APE) was shown to significantly reduce cytokine and chemokine mRNA levels in IL-1β-stimulated SW1353 and SW982 cells and attenuate the expression of proinflammatory cytokines and p38/AP-1 in SW1353 cells. APE was also shown to minimize the effect of osteolytic lesions in the knee joints of ACLT-induced osteoarthritic mice.

conclusionsAPE is a potent inhibitor of joint degeneration associated with OA.

Indexed as

ChondrocytesOsteoarthritisAnimalsAnti-Inflammatory AgentsCytokinesMiceMice, Inbred C57BLModels, TheoreticalPolysaccharidesRNA, MessengerAnti-Inflammatory AgentsCytokinesPolysaccharidesRNA, Messengerchondrocyteenteromorpha proliferainterleukin-1βosteoarthritisoxidative stress

Identifiers

PMID36250247
PMCPMC9924978
OpenAlexW4306399388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.