ArticleAging pathobiology and therapeutics2022
A mouse model of naturally occurring age-related cognitive impairment.
Article in Aging pathobiology and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Environmental Enrichment Attenuates Aging-Induced BBB Disruption and Cognitive Impairment with Activation of FNDC5/Irisin Signaling.International journal of molecular sciences · 2026Article
- From artery to memory: a comparative review of vascular cognitive impairment surgical models.Frontiers in aging neuroscience · 2026Review
- The Combination of Two Small Molecules Improves Neurological Parameters and Extends the Lifespan of C3H Strain Female Mice.Brain and behavior · 2025Article
- Age as a limiting factor for effectiveness of photostimulation of brain drainage and cognitive functions.Frontiers of optoelectronics · 2025Article
- Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations.GeroScience · 2025Review
- Effects of high-intensity interval training on physical and cognitive function in middle-aged male mice.Frontiers in aging · 2025Article
- Associations between folate metabolism biomarkers and cognitive impairment in older Chinese adults: a cross-sectional study.Frontiers in medicine · 2025Article
- Effect of JM-20 on Age-Related Cognitive Impairment in Mice.Neurochemical research · 2024Article
- Article
- Creative Commons 4.0 Exploring the complex interplay between anxiety, aging, and behavior in CB6F1 and C57BL/6 mice: implications for cognitive function.Aging pathobiology and therapeutics · 2024Article
- Intranasal GHK peptide enhances resilience to cognitive decline in aging mice.bioRxiv : the preprint server for biology · 2023Article
- Is aging "normal"?Aging pathobiology and therapeutics · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Age-related cognitive impairment (ARCI) is a neurological condition that affects millions of older people, but little is known about the increased risk of developing more severe neurodegeneration and dementia. Preclinical research is needed to understand the mechanisms of the impairment and the neuropathology associated with it. We have characterized a model of naturally occurring ARCI in the C57BL/6J mouse strain that shows an age-dependent development of cognitive impairment. As in people, some mice have little cognitive impairment while others have more severe cognitive impairment. Therefore, mice can be categorized as resistant or susceptible and the two groups can be studied for behavioral and neuropathology differences. Preliminary observations show no difference in strength and agility test scores between ARCI resistant and susceptible mice of either sex suggesting the cognitive impairment in ARCI susceptible mice is not accompanied by impairment in daily living activities, similar to ARCI in humans. The hippocampal area of the brain from ARCI susceptible mice shows evidence of an increase in the inflammatory cytokine MCP-1 compared to ARCI resistant mice, suggesting inflammation may be associated with ARCI. These preliminary observations suggest that ARCI in C57BL/6J mice could be a high-impact model to study how resilience to brain aging may predict resilience to dementia associated with Alzheimer's disease and other age-related neurological conditions.
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