ArticleJournal of the International Society of Sports Nutrition2022
The exercise metabolome: acute aerobic and anaerobic signatures.
Article in Journal of the International Society of Sports Nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed.
- Glycaemic Response to Acute Aerobic and Anaerobic Exercise Performed in the Morning or Afternoon in Healthy Subjects: A Crossover Trial.Journal of the International Society of Sports Nutrition · 2024Trial
- Effects of moderate-intensity continuous training on cardiac mitochondrial bioenergetics, oxidative balance, and mitochondrial dynamic in juvenile overnourished rats.Molecular and cellular biochemistry · 2026Article
- Serum metabolomic profiling reveals load-specific adaptations to resistance training.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Molecular Biomarkers of Training Responses: A Systems Framework for Exercise Adaptation and Athlete Monitoring.International journal of molecular sciences · 2026Review
- Sex differences in response to a short-term training program intervention in obese adolescents: a plasma metabolomics study.Biology of sex differences · 2026Article
- The Role of Exercise in Cardiovascular Metabolism and Its Importance for Adolescent Metabolic Health.Advances in experimental medicine and biology · 2026Review
- Exercise-specific post-translational modification signatures: unveiling precise regulatory mechanisms of molecular exercise language and cellular adaptation.Frontiers in sports and active living · 2026Review
- NMR-Based Metabolomics Reveals Position-Specific Signatures Associated with Physical Demands in Professional Soccer Players.Biomedicines · 2025Article
- Early changes in urineMetabolomics : Official journal of the Metabolomic Society · 2025Article
- Integrated Transcriptomic and Proteomic Analysis Reveals Differential Gene and Protein Expression and Signaling Pathways During a 20 Km Endurance Exercise and Recovery in Mongolian Horses.Animals : an open access journal from MDPI · 2025Article
- Cardiac Channelopathies: Clinical Diagnosis and Promising Therapeutics.Journal of the American Heart Association · 2025Review
- Differential Regulation of miRNA and Protein Profiles in Human Plasma-Derived Extracellular Vesicles via Continuous Aerobic and High-Intensity Interval Training.International journal of molecular sciences · 2025Article
- Exercise-induced effects on the metabolome of endurance and strength-trained athletes in comparison with sedentary subjects: A pilot study.Physiological reports · 2025Article
- Impact of different exercise modalities on neuroendocrine well-being markers among university students: a study of renalase and catecholamine responses.Frontiers in physiology · 2025Article
- Metabolomic and proteomic applications to exercise biomedicine.Translational exercise biomedicine · 2024Review
- Metabolic signatures of combined exercise and fasting: an expanded perspective on previous telomere length findings.Frontiers in aging · 2024Article
- Acute Aerobic Exercise Intensity on Working Memory and Vigilance After Nap Deprivation: Effects of Low-Intensity Deserve Attention.Nature and science of sleep · 2024Article
- Acute changes in the metabolome following resistance exercise combined with intake of different protein sources (cricket, pea, whey).Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Exercise Metabolome: Insights for Health and Performance.Metabolites · 2023Review
- Mass Sportrometry: An annual look back at applications of mass spectrometry in sport and exercise science.Analytical science advances · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Background: Exercise modality differentially alters body composition and physical performance. Metabolic changes underlying these outcomes can be tracked through assessment of circulating metabolites. Here, global responses to an acute bout of aerobic or anaerobic exercise were compared in the serum of male and female subjects using a discovery-based metabolomics platform. Methods: On separate days, 40 healthy, active participants completed 45 min of aerobic cycling or resistance exercise, and blood samples were collected at rest, immediately after (T1) and 1 hour post-exercise (T2) to examine the serum metabolomic landscape. Results: The two exercise metabolomes appeared more similar than different in this healthy cohort. Overall, metabolomic signatures of both exercise modalities were markedly altered from rest at T1, and returned toward baseline by T2. Metabolomic perturbations at T1 and the T1-T2 rate of recovery post-exercise were greater following aerobic cycling than resistance exercise. Shared signatures included elevations in purine metabolism, substrate catabolism and mobilization, and inflammatory signaling. Aerobic exercise resulted in greater substrate diversity and use of fatty acids, whereas resistance exercise displayed higher purine turnover and glycolytic flux. Discussion: Individual metabolite differences between conditions were seen in magnitude but not direction. Metabolomic signatures of the exercise responses appeared fairly robust across exercise modalities. An initial perturbation and subsequent shift toward recovery by an hour post-exercise defined the signature in our healthy cohort. The expedited recovery following aerobic cycling may be explained by globally elevated lipid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.