Evidence map›Paper›PMID 36249773›Full record

ReviewFrontiers in pharmacology2022

Understanding plant to extract ratios in botanical extracts.

Maria Monagas, Thomas Brendler, Josef Brinckmann, Steven Dentali, Stefan Gafner, Gabriel Giancaspro, Holly Johnson, James Kababick, Cuiying Ma, Hellen Oketch-Rabah and 3 more

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Sequential Fractionation ofFoods (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Green synthesis of magnetite (FeScientific reports · 2025
    Article
  11. Open veterinary journal · 2025
    Article
  12. Article
  13. Phytotoxic and Antifungal Effects ofPathogens (Basel, Switzerland) · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review of black cohosh-induced toxicity and adverse clinical effects.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria MonagasUnited States Pharmacopeia (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States.
Thomas BrendlerUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.
Josef BrinckmannUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.
Steven DentaliUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.
Stefan GafnerUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.
Gabriel GiancasproUnited States Pharmacopeia (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States.
Holly JohnsonUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.
James KababickUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.
Cuiying MaUnited States Pharmacopeia (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States.
Hellen Oketch-RabahUnited States Pharmacopeia (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States.
Pilar PaisUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.
Nandu SarmaUnited States Pharmacopeia (USP). Dietary Supplements and Herbal Medicines, Rockville, MD, United States.
Robin MarlesUnited States Pharmacopeia (USP). Botanical Dietary Supplements and Herbal Medicines Expert Committee, Rockville, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary supplement current good manufacturing practice (cGMP) requires establishment of quality parameters for each component used in the manufacture of a dietary supplement to ensure that specifications for the identity, purity, strength, composition, and limits on contaminants are met. Compliance with botanical extract ingredient specifications is assured by using scientifically valid methods of analysis, the results of which are reported on certificates of analysis (CoAs). However, CoAs routinely include additional data that are not amenable to verification through methods of analysis. Such descriptive information may include Plant to Extract ratios, which are ratios of the quantity of botanical article used in the manufacture of the extract to the quantity of extract obtained

Indexed as

botanical extractdrug to extract ratio (DER)genuine extractherbal medicinenative extractplant to extract ratio

Identifiers

PMID36249773
PMCPMC9561911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.