ArticleChemical engineering science2013
Synthetic biology strategies for synthesizing polyhydroxyalkanoates from unrelated carbon sources.
Article in Chemical engineering science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- A metabolic engineering strategy for producing poly-(3-hydroxyoctanoic acid) in Escherichia coli from glycerol.Metabolic engineering · 2025Article
- Biodegradability of polyhydroxyalkanoate (PHA) biopolyesters in nature: a review.Biodegradation · 2025Review
- Materials designed to degrade: structure, properties, processing, and performance relationships in polyhydroxyalkanoate biopolymers.Polymer chemistry · 2025Review
- Microbial Biosynthesis of Medium-Chain-Length Polyhydroxyalkanoate (mcl-PHA) from Waste Cooking Oil.Polymers · 2024Article
- Medium Chain Length Polyhydroxyalkanoate Production by Engineered Pseudomonas gessardii Using Acetate-formate as Carbon Sources.Journal of microbiology (Seoul, Korea) · 2024Article
- Light-driven synthetic microbial consortia: playing with an oxygen dilemma.Quantitative biology (Beijing, China) · 2023Review
- Bio-conversion of organic wastes towards polyhydroxyalkanoates.Biotechnology notes (Amsterdam, Netherlands) · 2023Review
- Surface display of carbonic anhydrase onSynthetic and systems biotechnology · 2022Article
- Polyhydroxyalkanoates, bacterially synthesized polymers, as a source of chemical compounds for the synthesis of advanced materials and bioactive molecules.Applied microbiology and biotechnology · 2021Review
- Recent advances in constructing artificial microbial consortia for the production of medium-chain-length polyhydroxyalkanoates.World journal of microbiology & biotechnology · 2021Review
- Developing Bioprospecting Strategies for Bioplastics Through the Large-Scale Mining of Microbial Genomes.Frontiers in microbiology · 2021Article
- Optimization of a Two-Species Microbial Consortium for Improved Mcl-PHA Production From Glucose-Xylose Mixtures.Frontiers in bioengineering and biotechnology · 2021Article
- Construction of a "nutrition supply-detoxification" coculture consortium for medium-chain-length polyhydroxyalkanoate production with a glucose-xylose mixture.Journal of industrial microbiology & biotechnology · 2020Article
- Production of medium chain length polyhydroxyalkanoate from acetate by engineered Pseudomonas putida KT2440.Journal of industrial microbiology & biotechnology · 2019Article
- Food waste conversion to microbial polyhydroxyalkanoates.Microbial biotechnology · 2017Review
- Engineered Fluorine Metabolism and Fluoropolymer Production in Living Cells.Angewandte Chemie (International ed. in English) · 2017Article
- Microbubble assisted polyhydroxybutyrate production in Escherichia coli.BMC research notes · 2016Article
- Production of polyhydroxybutyrate in oil palm (Elaeis guineensis Jacq.) mediated by microprojectile bombardment of PHB biosynthesis genes into embryogenic calli.Frontiers in plant science · 2015Article
- Production of medium chain length polyhydroxyalkanoate in metabolic flux optimized Pseudomonas putida.Microbial cell factories · 2014Article
- Secretion of polyhydroxybutyrate in Escherichia coli using a synthetic biological engineering approach.Journal of biological engineering · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Discovered in the 1920's, polyhydroxyalkanoates (PHA) are a naturally occurring class of biopolyesters that have long been touted as a renewable, biodegradable plastic alternative. Demand for sustainable products and over a half century of research have led to moderate commercial success of PHA. Yet, these materials are not pervasive. Therefore, an important question to address is, "what is the barrier that prevents widespread application of these materials?" PHA can be made from an incredibly diverse class of monomers that incorporate both simple and complex organic acids. Herein, we provide an updated list of unique PHA monomers that are substrates for a PHA polymerase. Unfortunately, most unique monomers are incorporated only after feeding a structurally related feedstock to a PHA accumulating bacterium. Therefore, we put forward an argument that research must now turn to developing feedstock-independent, synthetic pathways to produce an increased diversity of PHAs capable of competing with petroleum-derived plastics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.