ReviewACS omega2022
Recent Advances in the Catalytic Asymmetric Friedel-Crafts Reactions of Indoles.
Review in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 70 citations in OpenAlex.
- Enantioselective Rh-catalyzed addition of indoles to enones and the key role of the free N-H group with acyclic enones.Chemical science · 2026Article
- Catalytic asymmetric formal nucleophilic C2-substitution of indoles via C2-umpolung toward 2,3'-bisindole atropisomers.Nature communications · 2026Article
- Recent advances in catalytic approaches for the synthesis of 3-substituted indoles: mechanisms and strategies.RSC advances · 2025Review
- Towards MRI Study of Biointegration of Carbon-Carbon Composites with Ca-P Coatings.Nanomaterials (Basel, Switzerland) · 2025Article
- Saccharide success: exploring the role of d-fructose-based thioureas as organocatalysts for the enantioselective Friedel-Crafts alkylation reaction.RSC advances · 2025Article
- Access to Substituted 1,1-Diarylalkanes by Friedel-Crafts Benzylations Mediated by FeClChemSusChem · 2025Article
- Organocatalytic Enantioselective Friedel-Crafts Reaction of Phenanthrenequinones and Indoles.Molecules (Basel, Switzerland) · 2025Article
- Regio- and EnantioselectiveOrganic letters · 2024Article
- RSM optimization of Friedel-CraftsNanoscale advances · 2024Article
- Aza-Achmatowicz rearrangement coupled with intermolecular aza-Friedel-Crafts enables total syntheses of uleine and aspidosperma alkaloids.Chemical science · 2024Article
- Brønsted Acid-Catalyzed Synthesis of 4-Functionalized Tetrahydrocarbazol-1-ones from 1,4-Dicarbonylindole Derivatives.The Journal of organic chemistry · 2024Article
- Asymmetric Friedel-Crafts reaction of unsaturated carbonyl-tethered heteroarenesChemical science · 2023Article
- Catalytic asymmetric Friedel-Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral Yb(OTf)Scientific reports · 2023Article
- Asymmetric Catalytic Friedel-Crafts Reactions of Unactivated Arenes.Journal of the American Chemical Society · 2023Article
- Gram-Scale Total Synthesis of (±)-Ibogamine.Organic letters · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functionalized chiral indole derivatives are privileged and versatile organic frameworks encountered in numerous pharmaceutically active agents and biologically active natural products. The catalytic asymmetric Friedel-Crafts reaction of indoles, catalyzed by chiral metal complexes or chiral organocatalysts, is one of the most powerful and atom-economical approaches to access optically active indole derivatives. Consequently, a wide range of electrophilic partners including α,β-unsaturated ketones, esters, amides, imines, β,γ-unsaturated α-keto- and α-ketiminoesters, ketimines, nitroalkenes, and many others have been successfully employed to achieve a plethora of functionalized chiral indole moieties. In particular, strategies for C-H functionalization in the phenyl of indoles require incorporation of a directing or blocking group in the phenyl or azole ring of indole. The discovery of chiral catalysts which can control enantiodiscrimination has gained a great deal of attention in recent years. This review will provide an updated account on the application of the asymmetric Friedel-Crafts reaction of indoles in the synthesis of diverse chiral indole derivatives, covering the timeframe from 2011 to today.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.