ArticleEnvironmental epidemiology (Philadelphia, Pa.)2022
Joint association between ambient air pollutant mixture and pediatric asthma exacerbations.
Article in Environmental epidemiology (Philadelphia, Pa.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Climate change, environmental exposures, and pediatric asthma exacerbations: air pollution, temperature, and relative humidity.Pediatric research · 2026Review
- Extreme Cold Events and Pediatric Asthma Outpatient Visits: The Modifying Role of Ambient Carbon Monoxide and Sulfur Dioxide.Journal of asthma and allergy · 2026Article
- Beyond Single Pollutants: Mixture Analysis Methods in Air Pollution and Asthma Research.American journal of respiratory and critical care medicine · 2025Article
- Association of Annual Exposure to Air Pollution Mixture on Asthma Hospitalizations in the United States.American journal of respiratory and critical care medicine · 2025Article
- Seasonal extreme temperatures and short-term fine particulate matter increases pediatric respiratory healthcare encounters in a sparsely populated region of the intermountain western United States.Environmental health : a global access science source · 2024Article
- Seasonal extreme temperatures and short-term fine particulate matter increases child respiratory hospitalizations in a sparsely populated region of the intermountain western United States.Research square · 2023Article
- The Association between Drought Exposure and Respiratory-Related Mortality in the United States from 2000 to 2018.International journal of environmental research and public health · 2023Article
- Role of social determinants of health in differential respiratory exposure and health outcomes among children.BMC public health · 2023Article
- The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Exposure to air pollutants is known to exacerbate asthma, with prior studies focused on associations between single pollutant exposure and asthma exacerbations. As air pollutants often exist as a complex mixture, there is a gap in understanding the association between complex air pollutant mixtures and asthma exacerbations. We evaluated the association between the air pollutant mixture (52 pollutants) and pediatric asthma exacerbations. Method: This study focused on children (age ≤ 19 years) who lived in Douglas County, Nebraska, during 2016-2019. A seasonal-scale joint association between the outdoor air pollutant mixture adjusting for potential confounders (temperature, precipitation, wind speed, and wind direction) in relation to pediatric asthma exacerbation-related emergency department (ED) visits was evaluated using the generalized weighted quantile sum (qWQS) regression with repeated holdout validation. Results: We observed associations between air pollutant mixture and pediatric asthma exacerbations during spring (lagged by 5 days), summer (lag 0-5 days), and fall (lag 1-3 days) seasons. The estimate of the joint outdoor air pollutant mixture effect was higher during the summer season (adjusted-β Conclusion: There were associations between outdoor air pollutant mixture and pediatric asthma exacerbations during the spring, summer, and fall seasons. Among the 52 outdoor air pollutant metrics investigated, PM
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.