Evidence map›Paper›PMID 36249118›Full record

ArticleIranian journal of public health2022

Correlation between Ubiquitin E3 Ligases (

Leila Sabour Takanlou, Gulsah Cecener, Maryam Sabour Takanlou, Hulya Ozturk Nazlioglu, Havva Tezcan Unlu, Ozgen Isik, Unal Egeli, Berrin Tunca, Erdem Cubukcu, Sahsine Tolunay and 1 more

Open access · goldAbstract read
In one paragraph

Article in Iranian journal of public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Leila Sabour TakanlouDeparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Gulsah CecenerDeparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Maryam Sabour TakanlouDeparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Hulya Ozturk NazliogluDepartment of Medical Pathology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Havva Tezcan UnluDeparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Ozgen IsikDepartment of General Surgey, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Unal EgeliDeparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Berrin TuncaDeparment of Medical Biology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Erdem CubukcuDepartment of Medical Oncology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Sahsine TolunayDepartment of Medical Pathology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Mustafa Sehsuvar GokgozDepartment of General Surgey, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey.
Bursa Uludağ Üni̇versi̇tesi̇ · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Breast cancer is a heterogeneous disease and differences in the expression levels of the ER, PR, and HER2 the triplet of established biomarkers used for clinical decision-making have been reported among breast cancer patients. Furthermore, resistance to anti-estrogen and anti-HER2 therapies emerges in a considerable rate of breast cancer patients, and novel drug therapies are required. Several anomalous signaling pathways have been known in breast cancer have been known; heat shock protein 90 (HSP90) is one of the most plenty proteins in breast cells. The family of ubiquitin ligases such as SIAH1 and SIAH2 is known to specifically target misfolded proteins to the proteasome; also, they have been illustrated to play a role in RAS signaling and as an essential downstream signaling component required for EGFR/HER2 in breast cancer. Methods: The expression of Results: Conclusion: The

Indexed as

Breast cancerInvasive ductal carcinomaUbiquitin-protein ligases

Identifiers

PMID36249118
PMCPMC9546798
OpenAlexW4292262856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.