ArticleFrontiers in immunology2022
Malnutrition leads to increased inflammation and expression of tuberculosis risk signatures in recently exposed household contacts of pulmonary tuberculosis.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 23 citations in OpenAlex.
- Multidimensional Poverty and Implementation Reach of Household Contact Tracing for Tuberculosis in South Africa: Analysis of a Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Trial
- Host and pathogen factors modulate tuberculosis clinical severity independent of molecular bacterial burden: insights from a multicenter Ghanaian cohort.IJID regions · 2026Article
- Global, regional, and national tuberculosis burden associated with six suboptimal dietary exposures from 1990 to 2021: a comparative risk assessment based on the Global Burden of Disease Study 2021.Journal of thoracic disease · 2026Article
- Metagenomic Next-Generation Sequencing for Pulmonary Tuberculosis Diagnosis and Infection Risk Factor Analysis in AECOPD Patients: A Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice.Nature communications · 2026Article
- Hypercoagulability in Pulmonary Tuberculosis: Reduced Protein C and Free Protein S Predict Pulmonary Embolism-Evidence from a Prospective Romanian Cohort.Journal of clinical medicine · 2026Article
- Assessing mortality risk in pulmonary tuberculosis and severe malnutrition: development of the IIR marker via artificial intelligence.Scientific reports · 2026Article
- Reproducible Tools and Enhanced Computational Workflows for Batch Effect Evaluation of High-Throughput Data Using BatchQC.bioRxiv : the preprint server for biology · 2026Article
- Nutritional status and associated factors among adult patients with tuberculosis in public hospitals of Sidama Region, Ethiopia.PLOS global public health · 2026Article
- Analysis of the cross-study replicability of tuberculosis gene signatures using 49 curated human transcriptomic datasets.Tuberculosis (Edinburgh, Scotland) · 2025Article
- Knowledge and Prevalence of Latent Tuberculosis Infection: A Feasibility and Pilot Study in a Primary Healthcare Setting in Rural Eastern Cape, South Africa.International journal of environmental research and public health · 2025Article
- Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials.Frontiers in antibiotics · 2025Review
- Popularity of HIV self-tests may say more about the state of our primary care system than about the device itself.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2024Article
- New genetic biomarkers from transcriptome RNA-sequencing for Mycobacterium tuberculosis complex and Mycobacterium avium complex infections by bioinformatics analysis.Scientific reports · 2024Article
- Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection-a Multicenter Prospective Cohort Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Integrative analysis of multimodal patient data identifies personalized predictors of tuberculosis treatment prognosis.iScience · 2024Article
- Nutritionally acquired immunodeficiency must be addressed with the same urgency as HIV to end tuberculosis.BMC global and public health · 2024Review
- Diagnosis and treatment of latent tuberculosis infection among household contacts in inland Bahia, Brazil: a cross-sectional follow-up study.Sao Paulo medical journal = Revista paulista de medicina · 2024Article
- Article
- Incidence and Risk Factors of Active Tuberculosis Among Hospitalized Patients with Latent Tuberculosis Infection in China: A Cohort Study.Infection and drug resistance · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: Most individuals exposed to Methods: We utilized data from 50 tuberculin skin test positive household contacts of persons with TB - 18 malnourished participants (body mass index [BMI] < 18.5 kg/m2) and 32 controls (individuals with BMI ≥ 18.5 kg/m2). Whole blood RNA-sequencing was conducted to identify differentially expressed genes (DEGs). Ingenuity Pathway Analysis was applied to the DEGs to identify top canonical pathways and gene regulators. Gene enrichment methods were then employed to score the performance of published gene signatures associated with progression from LTBI to TB. Results: Malnourished individuals had increased activation of inflammatory pathways, including pathways involved in neutrophil activation, T-cell activation and proinflammatory IL-1 and IL-6 cytokine signaling. Consistent with known association of inflammatory pathway activation with progression to TB disease, we found significantly increased expression of the RISK4 (area under the curve [AUC] = 0.734) and PREDICT29 (AUC = 0.736) progression signatures in malnourished individuals. Conclusion: Malnourished individuals display a peripheral immune response profile reflective of increased inflammation and a concomitant increased expression of risk signatures predicting progression to TB. With validation in prospective clinical cohorts, TB risk biomarkers have the potential to identify malnourished LTBI for targeted therapy.
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