Evidence map›Paper›PMID 36248899›Full record

ArticleFrontiers in immunology2022

Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes

Elliott D SoRelle, Nicolás M Reinoso-Vizcaino, Gillian Q Horn, Micah A Luftig

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. A tonsil organoid model reveals Epstein-Barr virus-infected germinal center B cell states during primary infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Adoptive T-cell therapy for virus-associated diseases.Clinical microbiology reviews · 2025
    Review
  16. EBV INFECTION OUTCOMES DETERMINED BY MONOCYTE AND TbioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Epstein-Barr Virus in Multiple Sclerosis: Past, Present, and Future.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elliott D SoRelleDepartment of Molecular Genetics & Microbiology, Duke University, Durham, NC, United States.
Nicolás M Reinoso-VizcainoDepartment of Molecular Genetics & Microbiology, Duke University, Durham, NC, United States.
Gillian Q HornDepartment of Immunology, Duke University, Durham, NC, United States.
Micah A LuftigDepartment of Molecular Genetics & Microbiology, Duke University, Durham, NC, United States.

Funding

Viral Oncology Training GrantT32CA009111 · NCI · DUKE UNIVERSITY · PI LUFTIG, MICAH A. · 1985 to 2023
$8.9M
Targeting Apoptosis and Immune Control of Epstein-Barr Virus Infected Tonsillar B CellsR01DE025994 · NIDCR · DUKE UNIVERSITY · PI Micah Alan Luftig · 2016 to 2026
$5.0M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
NCI NIH HHS T32 CA009111NIAID NIH HHS T32 AI052077NIDCR NIH HHS R01 DE025994
6 · The paper itself

Abstract

Human B cells encompass functionally diverse lineages and phenotypic states that contribute to protective as well as pathogenic responses. Epstein-Barr virus (EBV) provides a unique lens for studying heterogeneous B cell responses, given its adaptation to manipulate intrinsic cell programming. EBV promotes the activation, proliferation, and eventual outgrowth of host B cells as immortalized lymphoblastoid cell lines (LCLs)

Indexed as

B-LymphocytesEpstein-Barr Virus InfectionsHerpesvirus 4, HumanAutoimmunityGerminal CenterHumansImmunoglobulin DPhenotypeToll-Like Receptor 7Immunoglobulin DToll-Like Receptor 7atypical memory B cellsautoimmunityB cellchronic infectionEpstein-Barr virusgerminal centerlymphoblastoid cellssingle-cell

Identifiers

PMID36248899
PMCPMC9554744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.