Evidence map›Paper›PMID 36248898›Full record

ArticleFrontiers in immunology2022

Cross-reactivity between vaccine antigens from the chitin deacetylase protein family improves survival in a mouse model of cryptococcosis.

Maureen M Hester, Lorena V N Oliveira, Ruiying Wang, Zhongming Mou, Diana Lourenco, Gary R Ostroff, Charles A Specht, Stuart M Levitz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Peripheral blood CD4The Journal of infection · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Inbred Mouse Models inJournal of fungi (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Immune evasion byFrontiers in immunology · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Maureen M HesterDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
Lorena V N OliveiraDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
Ruiying WangDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
Zhongming MouDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
Diana LourencoDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
Gary R OstroffProgram in Molecular Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
Charles A SpechtDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
Stuart M LevitzDepartment of Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, United States.
University of Massachusetts Chan Medical School · US

Funding

Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
ROLE OF MACROPHAGES IN CRYPTOCOCCAL INFECTIONSR01AI025780 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 1987 to 2019
$7.1M
Large Scale T Cell Epitope Discovery75N93019C00064 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAGE, KASIA · 2019 to 2024
$6.3M
Chitosan in CryptococcusR01AI072195 · NIAID · WASHINGTON UNIVERSITY · PI LODGE, JENNIFER K. · 2008 to 2018
$3.5M
A subunit Cryptococcus vaccineR01AI172154 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Stuart Michael Levitz · 2022 to 2026
$3.1M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Glucan Particles as a Vaccine Platform for Protective ImmunityR01AI102618 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LEVITZ, STUART MICHAEL · 2013 to 2016
$2.1M
NIAID NIH HHS 75N93019C00064NIAID NIH HHS R01 AI025780NIAID NIH HHS R01 AI072195NIAID NIH HHS R01 AI102618NIAID NIH HHS R01 AI125045NIAID NIH HHS R01 AI172154NIAID NIH HHS T32 AI095213
6 · The paper itself

Abstract

Meningitis due to the fungal pathogen

Indexed as

CryptococcosisCryptococcus neoformansAmidohydrolasesAnimalsAntigens, FungalDisease Models, AnimalGlucansInterferon-gammaMiceAmidohydrolasesAntigens, Fungalchitin deacetylaseGlucansInterferon-gammaacquired immunodeficiency syndromeCD4 T cellcross-protectionCryptococcusfungal vaccineprotein family

Identifiers

PMID36248898
PMCPMC9554598
OpenAlexW4297546456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.