Evidence map›Paper›PMID 36248887›Full record

ArticleFrontiers in immunology2022

Genetic susceptibility loci for

Wujuan Zhong, Avinash Kollipara, Yutong Liu, Yuhan Wang, Catherine M O'Connell, Taylor B Poston, Kacy Yount, Harold C Wiesenfeld, Sharon L Hillier, Yun Li and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Frontiers in immunology · 2025
    Article
  5. Fenofibrate suppressesFrontiers in cellular and infection microbiology · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Wujuan ZhongDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Avinash KolliparaDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Yutong LiuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Yuhan WangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Catherine M O'ConnellDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Taylor B PostonDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Kacy YountDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Harold C WiesenfeldThe University of Pittsburgh School of Medicine and the Magee-Womens Research Institute, Pittsburgh, PA, United States.
Sharon L HillierThe University of Pittsburgh School of Medicine and the Magee-Womens Research Institute, Pittsburgh, PA, United States.
Yun LiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Toni DarvilleDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Xiaojing ZhengDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · USMagee-Womens Research Institute · USUniversity of Pittsburgh · US

Funding

The UPMC Sexually Transmitted Infections Cooperative Research CenterU19AI084024 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIESENFELD, HAROLD C · 2009 to 2013
$12.9M
University of North Carolina - Chlamydia Vaccine Initiative (UNC-CVI)U19AI144181 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI · 2019 to 2023
$10.7M
Natural Immunity Against Chlamydia trachomatisR01AI119164 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI · 2016 to 2020
$3.6M
Identifying Biomarkers and Genetic Risk Factors Predictive of Reproductive SequelR33AI098660 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI · 2014 to 2016
$1.3M
NIAID NIH HHS R01 AI119164NIAID NIH HHS R33 AI098660NIAID NIH HHS U19 AI084024NIAID NIH HHS U19 AI144181
6 · The paper itself

Abstract

Objectives: Identify genetic loci of enhanced susceptibility to Methods: We performed an integrated analysis of DNA genotypes and blood-derived mRNA profiles from 200 Results: We identified Conclusions: We discovered genetic variants associated with altered risk for

Indexed as

Chlamydia InfectionsChlamydia trachomatisFemaleGenetic MarkersGenetic Predisposition to DiseaseHumansQuantitative Trait LociRNA, MessengerT-LymphocytesTryptophanGenetic MarkersRNA, MessengerTryptophanblood T cells and T cell subsetsCD151Chlamydial trachomatiscis-eQTLsgenetic marker for host susceptibilityintegrated analysis of DNA genotypes and human blood transcriptomeupper genital tract infection in women

Identifiers

PMID36248887
PMCPMC9562917
OpenAlexW4298111069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.