Evidence map›Paper›PMID 36248881›Full record

ReviewFrontiers in immunology2022

miR-aculous new avenues for cancer immunotherapy.

William W Tang, Kaylyn M Bauer, Cindy Barba, Huseyin Atakan Ekiz, Ryan M O'Connell

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025
    Review
  3. Liquid biopsy in lung cancer.Breathe (Sheffield, England) · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

William W TangDivison of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Kaylyn M BauerDivison of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Cindy BarbaDivison of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Huseyin Atakan EkizDepartment of Molecular Biology and Genetics, Izmir Institute of Technology, İzmir, Turkey.
Ryan M O'ConnellDivison of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, United States.
Huntsman Cancer Institute · USUniversity of Utah · USIzmir Institute of Technology · TR

Funding

T cell expressed miR-155 promotes antitumor immunity and immune checkpoint blockade responses in colon cancer through repression of Ship1F30CA260977 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI TANG, WILLIAM WEIHAO · 2021 to 2025
$252k
Melanoma NAMPT mediates resistance to the anti-proliferative effects of Interferons (IFNs) and IFN based immunotherapies such as STING AgonistsF31CA261096 · NCI · UNIVERSITY OF UTAH · PI BARBA, CINDY BEATRIZ JENNIFER · 2021 to 2023
$81k
NCI NIH HHS F30 CA260977NCI NIH HHS F31 CA261096
6 · The paper itself

Abstract

The rising toll of cancer globally necessitates ingenuity in early detection and therapy. In the last decade, the utilization of immune signatures and immune-based therapies has made significant progress in the clinic; however, clinical standards leave many current and future patients without options. Non-coding RNAs, specifically microRNAs, have been explored in pre-clinical contexts with tremendous success. MicroRNAs play indispensable roles in programming the interactions between immune and cancer cells, many of which are current or potential immunotherapy targets. MicroRNAs mechanistically control a network of target genes that can alter immune and cancer cell biology. These insights provide us with opportunities and tools that may complement and improve immunotherapies. In this review, we discuss immune and cancer cell-derived miRNAs that regulate cancer immunity and examine miRNAs as an integral part of cancer diagnosis, classification, and therapy.

Indexed as

MicroRNAsNeoplasmsHumansImmunotherapyMicroRNAscancer cellcancer immunity and immunotherapycell deathexosomesmetabolismmicroRNATME (tumor microenvironment)

Identifiers

PMID36248881
PMCPMC9554277
OpenAlexW4297329395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.