Evidence map›Paper›PMID 36248835›Full record

ArticleFrontiers in immunology2022

Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study.

Mitsuhiro Iyori, Andrew M Blagborough, Tetsushi Mizuno, Yu-Ichi Abe, Mio Nagaoka, Naoto Hori, Iroha Yamagoshi, Dari F Da, William F Gregory, Ammar A Hasyim and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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  5. A two-dose viral-vectoredFrontiers in immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Mitsuhiro IyoriLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Andrew M BlagboroughDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Tetsushi MizunoDepartment of Parasitology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
Yu-Ichi AbeLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Mio NagaokaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Naoto HoriLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Iroha YamagoshiLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Dari F DaDépartement de Biologie Médicale et Santé Publique, Unité Paludisme et Maladies Tropicales Négligées, Institut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
William F GregoryDepartment of Pathology, University of Cambridge, Cambridge, United Kingdom.
Ammar A HasyimLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Yutaro YamamotoLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Akihiko SakamotoLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Kunitaka YoshidaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Hiroaki MizukamiDivision of Gene Therapy, Jichi Medical University, Tochigi, Japan.
Hisatoshi ShidaInstitute for Genetic Medicine, Hokkaido University, Hokkaido, Japan.
Shigeto YoshidaLaboratory of Vaccinology and Applied Immunology, Kanazawa University School of Pharmacy, Kanazawa University, Ishikawa, Japan.
Kanazawa University · JPUniversity of Cambridge · GBHokkaido University · JPInstitut de Recherche en Sciences de la Santé · BFJichi Medical University · JP

Funding

Medical Research Council MR/N00227X/1Wellcome Trust
6 · The paper itself

Abstract

The Malaria Vaccine Technology Roadmap 2013 (World Health Organization) aims to develop safe and effective vaccines by 2030 that will offer at least 75% protective efficacy against clinical malaria and reduce parasite transmission. Here, we demonstrate a highly effective multistage vaccine against both the pre-erythrocytic and sexual stages of

Indexed as

AntimalarialsMalaria, FalciparumMalaria VaccinesAnimalsAntibodies, ProtozoanDependovirusDisease Models, AnimalHumansMiceProtozoan ProteinsAntibodies, ProtozoanAntimalarialsMalaria VaccinesProtozoan Proteinsadeno-associated virus (AAV)LC16m8ΔmalariaPfCSPPfs25plasmodium falciparumvaccine

Identifiers

PMID36248835
PMCPMC9558734
OpenAlexW4297997756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.