Evidence map›Paper›PMID 36248829›Full record

ArticleFrontiers in immunology2022

Vitamin C deficiency reveals developmental differences between neonatal and adult hematopoiesis.

Ira Phadke, Marie Pouzolles, Alice Machado, Josquin Moraly, Pedro Gonzalez-Menendez, Valérie S Zimmermann, Sandrina Kinet, Mark Levine, Pierre-Christian Violet, Naomi Taylor

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Natural novel vitamin C derivative, 2-Chinese herbal medicines · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Ira PhadkePediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Marie PouzollesPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Alice MachadoPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Josquin MoralyPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Pedro Gonzalez-MenendezInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, Centre National de la Recherche Scientifique (CNRS), Montpellier, France.
Valérie S ZimmermannPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Sandrina KinetInstitut de Génétique Moléculaire de Montpellier, University of Montpellier, Centre National de la Recherche Scientifique (CNRS), Montpellier, France.
Mark LevineMolecular and Clinical Nutrition Section, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Pierre-Christian VioletMolecular and Clinical Nutrition Section, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Naomi TaylorPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, United States.
Centre National de la Recherche Scientifique · FRNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · USInstitut de Génétique Moléculaire de Montpellier · FRInstitut des Maladies Génétiques Imagine · FRLaboratory of Excellence GR-Ex · FRNational Cancer Institute · US

Funding

YEAST MEMBRANE CYTOSKELETONP01DK032094 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI NARLA, MOHANDAS · 1987 to 2021
$26.7M
Reprogramming hematopoietic stem cell (HSC) differentiation via metabolic conditZIABC011924 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TAYLOR, NAOMI · 2019 to 2025
$9.0M
Vitamin C Biochemistry, Molecular Biology, /Recom IngestZ01DK054506 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI LEVINE, MARK A · 1998 to 2008
$768k
Intramural NIH HHS Z01 DK054506Intramural NIH HHS ZIA BC011924NIDDK NIH HHS P01 DK032094
6 · The paper itself

Abstract

Hematopoiesis, a process that results in the differentiation of all blood lineages, is essential throughout life. The production of 1x10

Indexed as

Ascorbic Acid DeficiencyMustelidaeScurvyAnimalsAscorbic AcidErythropoiesisFemaleGlucoseHumansL-Gulonolactone OxidaseMicePregnancyVitaminsAscorbic AcidGlucoseL-Gulonolactone OxidaseVitaminsanemiaascorbatedevelopmenterythropoiesisGULOhematopoiesisneonatalvitamin C

Identifiers

PMID36248829
PMCPMC9562198
OpenAlexW4298141242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.