Evidence map›Paper›PMID 36248818›Full record

ArticleFrontiers in immunology2022

On the clinical relevance of using complete high-resolution HLA typing for an accurate interpretation of posttransplant immune-mediated graft outcomes.

Maria Meneghini, Anna Perona, Elena Crespo, Frederike Bemelman, Petra Reinke, Ondrej Viklicky, Magali Giral, Eduard Palou, Alba Torija, Laura Donadeu and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Anti-HLA antibodies in lung transplantation: diagnostic pitfalls and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 5 countries.

Maria MeneghiniKidney Transplant Unit, Nephrology Department. Vall d'Hebron University Hospital, Barcelona, Spain.
Anna PeronaDepartment of Medicine, Barcelona University, Barcelona, Spain.
Elena CrespoVall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Frederike BemelmanRenal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Centers, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands.
Petra ReinkeBerlin Center for Advanced Therapies (BeCAT), Berlin Institute of Health Center for Regenerative Therapies (BCRT) and Department of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin Institute of Health, Berlin, Germany.
Ondrej ViklickyTransplant Laboratory, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czechia.
Magali GiralNantes Université, Inserm, Centre Hospitalier Universitaire (CHU) Nantes, Centre de Recherche en Transplantation et Immunologie UMR1064, Institut de Transplantation Urologie-Néphrologie (ITUN), Nantes, France.
Eduard PalouHistocompatibility Laboratory, Immunology Department. Hospital Clinic, Barcelona, Spain.
Alba TorijaVall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Laura DonadeuVall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Edoardo MelilliKidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain.
Jose ZuñigaKidney Transplant Unit, Nephrology Department. Vall d'Hebron University Hospital, Barcelona, Spain.
Anett SefrinBerlin Center for Advanced Therapies (BeCAT), Berlin Institute of Health Center for Regenerative Therapies (BCRT) and Department of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin Institute of Health, Berlin, Germany.
Nils LachmannHLA- Laboratory, Charité- Universitätsmedizin Berlin, Berlin, Germany.
Liu HuRenal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Centers, Academic Medical Center - University of Amsterdam, Amsterdam, Netherlands.
Petra HrubaTransplant Laboratory, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czechia.
Cécile Guillot-GueguenNantes Université, Inserm, Centre Hospitalier Universitaire (CHU) Nantes, Centre de Recherche en Transplantation et Immunologie UMR1064, Institut de Transplantation Urologie-Néphrologie (ITUN), Nantes, France.
Sophie BrouardNantes Université, Inserm, Centre Hospitalier Universitaire (CHU) Nantes, Centre de Recherche en Transplantation et Immunologie UMR1064, Institut de Transplantation Urologie-Néphrologie (ITUN), Nantes, France.
Josep GrinyoDepartment of Medicine, Barcelona University, Barcelona, Spain.
Oriol BestardKidney Transplant Unit, Nephrology Department. Vall d'Hebron University Hospital, Barcelona, Spain.
Vall d'Hebron Institut de Recerca · ESAmsterdam University Medical Centers · NLBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEInstitute of Clinical and Experimental Medicine · CZUniversitat Autònoma de Barcelona · ESUniversitat de Barcelona · ESBellvitge University Hospital · ESCharité - Universitätsmedizin Berlin · DEHospital Clínic de Barcelona · ESInserm · FRInstitut de Transplantation Urologie en Nephrologie · FRNantes Université · FRVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete and high-resolution (HR) HLA typing improves the accurate assessment of donor-recipient compatibility and pre-transplant donor-specific antibodies (DSA). However, the value of this information to identify

Indexed as

Graft RejectionHLA AntigensGraft SurvivalHistocompatibility TestingHLA-C AntigensHumansHLA AntigensHLA-C Antigensallograft rejectiondonor-specific antibodiesHLA typingkidney transplantationprecision medicine

Identifiers

PMID36248818
PMCPMC9559221
OpenAlexW4297997000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.