Evidence map›Paper›PMID 36248808›Full record

ReviewFrontiers in immunology2022

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment.

Bayley R McRitchie, Billur Akkaya

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bayley R McRitchieDepartment of Neurology, The College of Medicine, The Ohio State University, Columbus, OH, United States.
Billur AkkayaDepartment of Neurology, The College of Medicine, The Ohio State University, Columbus, OH, United States.
The Ohio State University · US

Funding

Deciphering the specificity and molecular mechanisms of regulatory T cells using novel approachesDP2AI154451 · NIAID · OHIO STATE UNIVERSITY · PI Billur Akkaya · 2022 to 2026
$2.3M
NIAID NIH HHS DP2 AI154451
6 · The paper itself

Abstract

The concept of cancer immunotherapy has gained immense momentum over the recent years. The advancements in checkpoint blockade have led to a notable progress in treating a plethora of cancer types. However, these approaches also appear to have stalled due to factors such as individuals' genetic make-up, resistant tumor sub-types and immune related adverse events (irAE). While the major focus of immunotherapies has largely been alleviating the cell-intrinsic defects of CD8

Indexed as

NeoplasmsTumor MicroenvironmentCD8-Positive T-LymphocytesHumansImmunotherapyT-Lymphocytes, Regulatoryimmunotherapyregulatory T cellT cell exhaustionTreg, mechanismtumor

Identifiers

PMID36248808
PMCPMC9562032
OpenAlexW4298146998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.