Evidence map›Paper›PMID 36248710›Full record

SynthesisPeerJ2022

Association between hypomagnesemia and mortality among dialysis patients: a systematic review and meta-analysis.

Chi-Ya Huang, Chi-Chen Yang, Kuo-Chuan Hung, Ming-Yan Jiang, Yun-Ting Huang, Jyh-Chang Hwang, Chih-Chieh Hsieh, Min-Hsiang Chuang, Jui-Yi Chen

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chi-Ya Huang *Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Chi-Chen Yang *Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Kuo-Chuan HungDepartment of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan.
Ming-Yan JiangDivision of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Yun-Ting HuangDivision of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Jyh-Chang HwangDivision of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Chih-Chieh HsiehDivision of Nephrology, Department of Internal Medicine, Pingtung Christian Hospital, Pingtung, Taiwan.
Min-Hsiang ChuangDepartment of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Jui-Yi ChenDivision of Nephrology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.
Chi Mei Medical Center · TWChia Nan University of Pharmacy and Science · TWPingtung Christian Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malnutrition-inflammation-atherosclerosis (MIA) syndrome is caused by the inflammatory cytokines in end stage renal disease (ESRD) patients, and MIA complex-related factors may be associated with hypomagnesemia and mortality. However, the association between serum magnesium level and mortality for dialysis patients is still not clear. Additionally, no meta-analysis has investigated the impact of serum magnesium on peritoneal dialysis and hemodialysis, separately. Methods: We searched published studies in PubMed, Embase, Cochrane, Collaboration Central Register of Controlled Clinical Trials, and Cochrane Systematic Reviews through April 2022. Studies associated with serum magnesium and all-cause mortality or cardiovascular (CV) mortality in ESRD on kidney replacement therapy (KRT) patients were included. A hazard ratio (HR) with 95% confidence intervals (CI) was used to report the outcomes. Results: Twenty-one studies involving 55,232 patients were included. Overall, there was a significant association between hypomagnesemia and all-cause mortality for dialysis patients (HR: 1.67, 95% CI [1.412-2.00], Conclusions: Hypomagnesemia may be a significant risk factor for all-cause mortality and CV mortality in KRT patients, especially in those receiving hemodialysis. However, because of the limited certainty of evidence, more studies are required to investigate this association.

Indexed as

Kidney Failure, ChronicPeritoneal DialysisHumansInflammationMagnesiumRenal DialysisRisk FactorsMagnesiumDialysisHemodialysisHypomagnesemiaMagnesiumMortality

Identifiers

PMID36248710
PMCPMC9563282
OpenAlexW4304175287

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.