ArticleFrontiers in neuroscience2022
Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- White Blood Cells in Neurodegenerative Diseases in the Context of Neuroinflammation.Molecular neurobiology · 2025Review
- Early immune system changes in amyotrophic lateral sclerosis correlate with later disease progression.Med (New York, N.Y.) · 2025Article
- The causal effect of natural killer cells on COVID-19 infection, hospitalization and severity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Causal role of myeloid cells in Parkinson's disease: Mendelian randomization study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Peripheral Immune Profiles Predict ALS Progression in an Age- and Sex-Dependent Manner.Neurology(R) neuroimmunology & neuroinflammation · 2024Article
- Identifying the causal relationship between immune factors and osteonecrosis: a two-sample Mendelian randomization study.Scientific reports · 2024Article
- The role of CD56Journal of neuroinflammation · 2024Review
- Exploring the causal relationship between B lymphocytes and Parkinson's disease: a bidirectional, two-sample Mendelian randomization study.Scientific reports · 2024Article
- The peripheral immune cell counts and mouth ulcers: A two-sample Mendelian randomization study.Heliyon · 2024Article
- Causal association between immune cells and lung cancer risk: a two-sample bidirectional Mendelian randomization analysis.Frontiers in immunology · 2024Article
- Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia.Journal of pregnancy · 2024Article
- Evaluating the link between immune characteristics and attention deficit hyperactivity disorder through a bi-directional Mendelian randomization study.Frontiers in immunology · 2024Article
- Exploring risk factors for autoimmune diseases complicated by non-hodgkin lymphoma through regulatory T cell immune-related traits: a Mendelian randomization study.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Observational studies have suggested that peripheral immune disorders are associated with amyotrophic lateral sclerosis (ALS). Previous studies predominantly focused on changes in adaptive immunity. However, emerging evidence showed natural killer (NK) cells, an essential component of innate immunity, were involved in the degeneration of motor neurons. However, the causal relationship between dysregulated NK cells-related immune traits and ALS remains unclear. Objective: This study aimed to explore the causal relationship between NK cells-related immune traits and the risk of ALS. Materials and methods: Single nucleotide polymorphisms (SNPs) significantly associated with NK cells-related immune traits were selected as instrumental variables to estimate their causal effects on ALS. SNPs from a genome-wide association study (GWAS) on NK cells-related immune traits were used as exposure instruments, including an absolute NK-cells count, absolute HLA-DR Results: Each one standard deviation increase in the expression levels of CD16 Conclusion: Our results suggest that higher expression levels of CD16
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