Evidence map›Paper›PMID 36248617›Full record

ArticleEJHaem2022

Humoral and cellular immune response in patients with hematological disorders after two doses of BNT162b2 mRNA COVID-19 vaccine: A single-center prospective observational study (NCT05074706).

Elisa Bossi, Andrea Aroldi, Lorenza Maria Borin, Luisa Verga, Diletta Fontana, Federica Cocito, Beatrice Manghisi, Giovanni Rindone, Fabrizio Cavalca, Alessia Ripamonti and 7 more

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in EJHaem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05074706 (Evaluation of the Immune Response to Sars-Covid-19), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05074706 completednot on this map

Evaluation of the Immune Response to Sars-Covid-19 (Cov-2) Vaccines in Haematological Patients: Prospective Single Center Study

TypeobservationalSponsorUniversity of Milano BicoccaRan2021 to 2022Enrolled700ConditionsHematologic DiseasesArmsIgG antibodies to Sars-Cov-2, QuantiFERON SARS-CoV-2 test
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Elisa BossiDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0003-1303-9580
Andrea AroldiDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0002-3428-5353
Lorenza Maria BorinDepartment of Hematology San Gerardo Hospital Monza Italy.
Luisa VergaDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0003-1142-8435
Diletta FontanaDepartment of Medicine and Surgery University of Milano-Bicocca Milano Italy.ORCID https://orcid.org/0000-0003-1633-6310
Federica CocitoDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0002-8700-8229
Beatrice ManghisiDepartment of Hematology San Gerardo Hospital Monza Italy.
Giovanni RindoneDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0001-9244-4407
Fabrizio CavalcaDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0002-5819-9476
Alessia RipamontiDepartment of Hematology San Gerardo Hospital Monza Italy.
Monica RaggiMicrobiology Laboratory San Gerardo Hospital Monza Italy.
Sergio Maria Ivano MalandrinMicrobiology Laboratory San Gerardo Hospital Monza Italy.
Annalisa CavalleroMicrobiology Laboratory San Gerardo Hospital Monza Italy.
Laura AntoliniDepartment of Medicine and Surgery University of Milano-Bicocca Milano Italy.ORCID https://orcid.org/0000-0003-1040-4191
Diego BonardiDepartment of Hematology San Gerardo Hospital Monza Italy.
Rocco Giovanni PiazzaDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0003-4198-9620
Carlo Gambacorti-PasseriniDepartment of Hematology San Gerardo Hospital Monza Italy.ORCID https://orcid.org/0000-0001-6058-515X
Azienda Ospedaliera San Gerardo · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematological patients at higher risk of severe COVID-19 were excluded from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine trials. In this single-center observational prospective study (NCT05074706), we evaluate immune response in the hematological patients followed at the Hematological Division of San Gerardo Hospital, Monza (Italy) deemed to be severely immunosuppressed after vaccination with two doses of the BNT162b2 vaccine. Anti-SARS-CoV-2 immunoglobulin G titers above the cutoff value of 33.8 BAU/ml were detected in 303 (80.2%) out of the 378 patients enrolled. Patients with lymphoproliferative disorders had a significant lower probability of immunization (43.2% vs. 88.4%,

Indexed as

cellular immune responseCOVID‐19hematological disordersmRNA vaccineseroconversion

Identifiers

PMID36248617
PMCPMC9538646
OpenAlexW4293553477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.