Evidence map›Paper›PMID 36248064›Full record

ArticleFuture science OA2022

The promising role of hypoxia-resistant insulin-producing cells in ameliorating diabetes mellitus

Hanaa H Ahmed, Hadeer A Aglan, Hanan H Beherei, Mostafa Mabrouk, Nadia S Mahmoud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hanaa H AhmedHormones Department, Medical Research & Clinical Studies Institute, National Research Centre, Giza, 12622, Egypt.ORCID https://orcid.org/0000-0001-8642-9251
Hadeer A AglanHormones Department, Medical Research & Clinical Studies Institute, National Research Centre, Giza, 12622, Egypt.ORCID https://orcid.org/0000-0003-0837-0172
Hanan H BehereiRefractories, Ceramics & Building Materials Department, Advanced Materials Technology & Mineral Resources Research Institute, National Research Centre, Giza, 12622, Egypt.ORCID https://orcid.org/0000-0001-5885-2845
Mostafa MabroukRefractories, Ceramics & Building Materials Department, Advanced Materials Technology & Mineral Resources Research Institute, National Research Centre, Giza, 12622, Egypt.ORCID https://orcid.org/0000-0003-3330-6762
Nadia S MahmoudHormones Department, Medical Research & Clinical Studies Institute, National Research Centre, Giza, 12622, Egypt.ORCID https://orcid.org/0000-0002-9085-4063
National Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This study aimed to evaluate the efficacy of hypoxia-persistent insulin-producing cells (IPCs) against diabetes Materials & methods: Mesenchymal stem cells (MSCs) differentiation into IPCs in the presence of Se/Ti (III) or CeO Results: MSCs were differentiated into functional IPCs. IPCs exhibited overexpression of anti-apoptotic genes and down-expression of hypoxia and apoptotic genes. IPCs implantation elicited glucose depletion and elevated insulin, HK and G6PD levels. They provoked Conclusion: The chosen nanomaterials were impressive in generating hypoxia-resistant IPCs that could be an inspirational strategy for curing diabetes.

Indexed as

diabetes mellitushypoxiainsulin-producing cellsmesenchymal stem cellsnanomaterials

Identifiers

PMID36248064
PMCPMC9540411
OpenAlexW4295570942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.