ArticleFrontiers in aging neuroscience2022
Gait decline while dual-tasking is an early sign of white matter deterioration in middle-aged and older adults.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Cortical activation, gait performance, and muscle activation during dual-task walking in older adults with mild cognitive impairment.BMC geriatrics · 2026Article
- Alterations of diffusion kurtosis measures in gait-related white matter in the "ON-OFF state" of Parkinson's disease.Chinese medical journal · 2025Article
- Wearable sensors and machine learning fusion-based fall risk prediction in covert cerebral small vessel disease.Frontiers in neuroscience · 2025Article
- Exploring the challenges of avoiding collisions with virtual pedestrians using a dual-task paradigm in individuals with chronic moderate to severe traumatic brain injury.Journal of neuroengineering and rehabilitation · 2024Article
- CRP, but not fibrinogen, is associated with gait speed as early as middle age, in females but not males.Scientific reports · 2023Article
- Spatiotemporal gait characteristics during single- and dual-task walking are associated with the burden of cerebral small vessel disease.Frontiers in neurology · 2023Article
- Robust Human Gait Speed Recognition Under Non-Ideal Conditions for Suspension-Assisted Walking Systems.Healthcare technology lettersArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of white matter integrity (WMI) is associated with gait deficits in middle-aged and older adults. However, these deficits are often only apparent under cognitively demanding situations, such as walking and simultaneously performing a secondary cognitive task. Moreover, evidence suggests that declining executive functions (EF) are linked to gait decline, and their co-occurrence may point to a common underlying pathology, i.e., degeneration of shared brain regions. In this study, we applied diffusion tensor imaging (DTI) and a standardized gait assessment under single- and dual-tasking (DT) conditions (walking and subtracting) in 74 middle-aged and older adults without any significant gait or cognitive impairments to detect subtle WM alterations associated with gait decline under DT conditions. Additionally, the Trail Making Test (TMT) was used to assess EF, classify participants into three groups based on their performance, and examine a possible interaction between gait, EF, and WMI. Gait speed and subtracting speed while dual-tasking correlated significantly with the fractional anisotropy (FA) in the bilateral anterior corona radiata (highest
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