Evidence map›Paper›PMID 36247921›Full record

ArticleMovement disorders clinical practice2022

Characterization of Non-Motor Fluctuations Using the Movement Disorder Society Non-Motor Rating Scale.

Daniel Johannes van Wamelen, Silvia Rota, Anette Schrag, Alexandra Rizos, Pablo Martinez-Martin, Daniel Weintraub, Kallol Ray Chaudhuri

Open access · hybridAbstract read
In one paragraph

Article in Movement disorders clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Gender differences in non-motor fluctuations in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Daniel Johannes van WamelenDivision of Neuroscience, Department of Basic & Clinical Neuroscience, King's College London Institute of Psychiatry, Psychology & Neuroscience London United Kingdom.ORCID https://orcid.org/0000-0003-0921-5158
Silvia RotaDivision of Neuroscience, Department of Basic & Clinical Neuroscience, King's College London Institute of Psychiatry, Psychology & Neuroscience London United Kingdom.
Anette SchragDepartment of Clinical and Movement Neurosciences UCL Institute of Neurology, University College London London United Kingdom.ORCID https://orcid.org/0000-0002-9872-6680
Alexandra RizosDivision of Neuroscience, Department of Basic & Clinical Neuroscience, King's College London Institute of Psychiatry, Psychology & Neuroscience London United Kingdom.
Pablo Martinez-MartinCenter for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED) Carlos III Institute of Health Madrid Spain.
Daniel WeintraubDepartment of Psychiatry and Neurology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA USA.ORCID https://orcid.org/0000-0003-0633-7168
Kallol Ray ChaudhuriDivision of Neuroscience, Department of Basic & Clinical Neuroscience, King's College London Institute of Psychiatry, Psychology & Neuroscience London United Kingdom.
King's College London · GBBiomedical Research Networking Center on Neurodegenerative Diseases · ESNeurosciences Institute · USRadboud University Nijmegen · NLVeterans Health Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-motor fluctuations (NMF) in people with Parkinson's disease (PwP) are clinically important yet understudied. Objective: To study NMF in PwP using both the Movement Disorder Society Non-Motor Rating Scale (MDS-NMS) NMF subscale and wearable sensors. Methods: We evaluated differences in overall burden of NMF and of specific NMF across disease durations: <2 years (n = 33), 2-5 years (n = 35), 5-10 years (n = 33), and > 10 years (n = 31). In addition, wearable triaxial sensor output was used as an exploratory outcome for early morning "off" periods. Results: Significant between-group differences were observed for MDS-NMS NMF total scores ( Conclusions: Non-motor fluctuations prevalence in PwP increases with disease duration, but in a pattern different from motor fluctuations. Moreover, NMF can occur in PwP without dyskinesia, and in those with NMF the severity of NMF increases most during years 2-5 after diagnosis.

Indexed as

fluctuationsnon‐motor fluctuationsnon‐motor symptomsParkinson's diseaseprogressionwearable sensor

Identifiers

PMID36247921
PMCPMC9547143
OpenAlexW4285729276

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.